1. | Brickley SG, Revilla V, Cull-Candy SG, Wisden W and Farrant M. (2001) Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409:88-92 [Journal] . |
Neuron | Compartment | Property | Connectivity | Notes |
---|---|---|---|---|
Cerebellum interneuron granule GLU cell | Soma | GabaA | . | Granule cells compensate for the lack GABAA receptors (in somatic location? ) by expressing the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance so as to maintain normal neuronal behaviour; this finding highlight the importance of GABAA receptor-mediated background inhibition (Brickley SG et al, 20011 ). |
Cerebellum interneuron granule GLU cell | Soma | I Potassium | . | Granule cells that lack GABAA receptors (in somatic location? ) express the two-pore-domain K+ channel TASK-1, a voltage-independent K + conductance, so as to maintain normal neuronal behaviour (Brickley SG et al, 20011 ). Importance for membrane excitability of an GABAB receptor-activated inward-rectifying potassium current, sensitive to pertussis toxin and barium (Slesinger PA et al, 19972 ). Cerebellar granule cells from young rats (postnatal days 1-9) possess voltage-activated inward Na+ current as well as two types of K+ current, IA and IK (Cull-Candy SG et al, 19893 ). Single-channel and whole-cell recording identified three types of current: a transient inward sodium current and a transient and a sustained outward potassium current (Jalonen T et al, 19904 ). |
Classical References: first publications on each compartmental property; search PubMed for complete list | |
1. | Brickley SG, Revilla V, Cull-Candy SG, Wisden W and Farrant M. (2001) Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409:88-92 [Journal] . |
2. | Slesinger PA, Stoffel M, Jan YN and Jan LY. (1997) Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proc Natl Acad Sci U S A 94:12210-7. |
3. | Cull-Candy SG, Marshall CG and Ogden D. (1989) Voltage-activated membrane currents in rat cerebellar granule neurones. J Physiol 414:179-99. |
4. | Jalonen T, Johansson S, Holopainen I, Oja SS and Arhem P. (1990) Single-channel and whole-cell currents in rat cerebellar granule cells. Brain Res 535:33-8. |