133. McCormick DA and von Krosigk M. (1992) Corticothalamic activation modulates thalamic firing through glutamate fimetabotropicfi receptors. Proc Natl Acad Sci U S A 89:2774-8.

NeuronCompartmentPropertyConnectivityNotes
Thalamus geniculate nucleus/lateral principal neuronSomaI K,leak.This current is reduced by activation of the metabotropic glutamate receptors (McCormick DA and von Krosigk M, 1992 [guinea pig ]133 ).
Thalamus geniculate nucleus/lateral principal neuronDistal equivalent dendritemGluRCorticogeniculate input (T)Unlike the retinogeniculate input, the corticogeniculate input is received by both ionotropic and metabotropic glutamate receptors (McCormick DA and von Krosigk M, 1992 [guinea pig ]133 , SOBIV p316). A study indicates that synaptic activation of these receptors increases inhibitory activity in relay neurons by increasing output of presynaptic dendrites (Govindaiah A and Cox CL, 2004476 ).
Thalamus geniculate nucleus/lateral principal neuronMiddle equivalent dendritemGluRCorticogeniculate input (T)Unlike the retinogeniculate input, the corticogeniculate input is received by both ionotropic and metabotropic glutamate receptors (McCormick DA and von Krosigk M, 1992 [guinea pig ]133 , SOBIV p316). A study indicates that synaptic activation of these receptors increases inhibitory activity in relay neurons by increasing output of presynaptic dendrites (Govindaiah A and Cox CL, 2004476 ).

References
133. McCormick DA and von Krosigk M. (1992) Corticothalamic activation modulates thalamic firing through glutamate fimetabotropicfi receptors. Proc Natl Acad Sci U S A 89:2774-8.
476. Govindaiah A and Cox CL. (2004) Synaptic activation of metabotropic glutamate receptors regulates dendritic outputs of thalamic interneurons. Neuron 41:611-23.
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