Hippocampus CA3 pyramidal GLU cell | Middle apical dendrite | GabaA | CA3 Basket Cell terminals (T) | Intracellular recording from organotypic rat hippocampal cultures have shown that approximately 25% of single spikes in CA3 pyramidal neurons are followed by IPSPs at a fixed latency, presumeably a result of feedback inhibition from inhibitory interneurons. The addition of bicuculline (a competitive GABA(A) antagonist) completely abolished these responses, but they were insensitive to CGP35348, a GABA(B) antagonist (Fortunato C et al, 19961 ). There is also evidence that Zn+ can modulate bicuculline-sensitive responses to GABA early in development in rat (studied less than 8 days old)(Martina M et al, 1996 [rat]2 ). |
Hippocampus CA3 pyramidal GLU cell | Soma | GabaA | CA3 Basket Cell terminals (T) | Intracellular recording from organotypic rat hippocampal cultures have shown that approximately 25% of single spikes in CA3 pyramidal neurons are followed by IPSPs at a fixed latency, presumeably a result of feedback inhibition from inhibitory interneurons. The addition of bicuculline (a competitive GABA(A) antagonist) completely abolished these responses, but they were insensitive to CGP35348, a GABA(B) antagonist (Fortunato C et al, 19961 ). There is also evidence that Zn+ can modulate bicuculline-sensitive responses to GABA early in development in rat (studied less than 8 days old)(Martina M et al, 1996 [rat]2 ). |