145. Honoré T, Davies SN, Drejer J, Fletcher EJ, Jacobsen P, Lodge D and Nielsen FE. (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701-3.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA1 pyramidal cellMiddle apical dendriteAMPA.The Schaeffer collateral/commissural pathway elicits EPSPs in CA1 that have a large AMPA receptor-mediated component that can be blocked by CNQX (Honoré T et al, 1988 [rat ]145 ). (Reviewed in Randall AD and Collingridge GL, 1992142 ).EM showed colocalization at axodendritic asymmetric synapses within the CA1 subfield of rat hippocampus. AMPA/NMDA receptor colocalization was found in non-GABAergic dendritic shafts as well as dendritic spines, suggesting that excitatory neuronal transmission in CA1 neurons may generally involve activation of both NMDA and AMPA receptor subunits at a single synapse (He Y et al, 1998250 ). Using outside-out patches and a fast application system the properties and distribution of synaptic glutamate receptors an approximately twofold increase in AMPA-mediated current was observed in the dendritic region that receives a uniform density of Schaffer collateral input (100-250um from soma) (Andrasfalvy BK and Magee JC, 2001299 ).

References
145. Honoré T, Davies SN, Drejer J, Fletcher EJ, Jacobsen P, Lodge D and Nielsen FE. (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701-3.
142. Randall AD and Collingridge GL. (1992) Amino acid receptor-mediated synaptic currents in the CA1 region of the hippocampus. Ion Channels 3:63-81.
250. He Y, Janssen WG and Morrison JH. (1998) Synaptic coexistence of AMPA and NMDA receptors in the rat hippocampus: a postembedding immunogold study. J Neurosci Res 54:444-9 [Journal] .
299. Andrasfalvy BK and Magee JC. (2001) Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons. J Neurosci 21:9151-9.
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