154. Fortunato C, Debanne D, Scanziani M, Gahwiler BH and Thompson SM. (1996) Functional characterization and modulation of feedback inhibitory circuits in area CA3 of rat hippocampal slice cultures. Eur J Neurosci 8:1758-68.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA3 pyramidal cellMiddle apical dendriteGabaACA3 Basket Cell terminals (T)Intracellular recording from organotypic rat hippocampal cultures have shown that approximately 25% of single spikes in CA3 pyramidal neurons are followed by IPSPs at a fixed latency, presumeably a result of feedback inhibition from inhibitory interneurons. The addition of bicuculline (a competitive GABA(A) antagonist) completely abolished these responses, but they were insensitive to CGP35348, a GABA(B) antagonist (Fortunato C et al, 1996154 ). There is also evidence that Zn+ can modulate bicuculline-sensitive responses to GABA (Martina M et al, 1996 [rat ]165 ) early in development in rat (studied <8 days old).
Hippocampus CA3 pyramidal cellSomaGabaACA3 Basket Cell terminals (T)Intracellular recording from organotypic rat hippocampal cultures have shown that approximately 25% of single spikes in CA3 pyramidal neurons are followed by IPSPs at a fixed latency, presumeably a result of feedback inhibition from inhibitory interneurons. The addition of bicuculline (a competitive GABA(A) antagonist) completely abolished these responses, but they were insensitive to CGP35348, a GABA(B) antagonist (Fortunato C et al, 1996154 ). There is also evidence that Zn+ can modulate bicuculline-sensitive responses to GABA (Martina M et al, 1996 [rat ]165 ) early in development in rat (studied <8 days old).

References
154. Fortunato C, Debanne D, Scanziani M, Gahwiler BH and Thompson SM. (1996) Functional characterization and modulation of feedback inhibitory circuits in area CA3 of rat hippocampal slice cultures. Eur J Neurosci 8:1758-68.
165. Martina M, Mozrzymas JW, Strata F and Cherubini E. (1996) Zinc modulation of bicuculline-sensitive and -insensitive GABA receptors in the developing rat hippocampus. Eur J Neurosci 8:2168-76.
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