166. McDonough SI, Swartz KJ, Mintz IM, Boland LM and Bean BP. (1996) Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC. J Neurosci 16:2612-23.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA3 pyramidal cellSomaI N.In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, N-currents were found in 63% of the patches and found to have single channel conductances of 14 pS (Johnston et al. 1992; Fisher RE et al, 1990153 ). Bath application of omega-conotoxin MVIIC blocked (with rapid kinetics) approximately 20% of the high-voltage activated Ca2+ current, suggesting the presence of N-channels measured in whole-cell recordings (McDonough SI et al, 1996 [rat ]166 ).
Hippocampus CA3 pyramidal cellSomaI p,q.Bath application of omega-conotoxin MVIIC (an antagonist of N and P channels) blocked (with slow kinetics) approximately 30% of the high-voltage activated Ca2+ current measured in whole-cell recordings (McDonough SI et al, 1996 [rat ]166 ).

References
153. Fisher RE, Gray R and Johnston D. (1990) Properties and distribution of single voltage-gated calcium channels in adult hippocampal neurons. J Neurophysiol 64:91-104 [Journal] .
166. McDonough SI, Swartz KJ, Mintz IM, Boland LM and Bean BP. (1996) Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC. J Neurosci 16:2612-23.
_5/22/2018 5:34:36 PM