189. Salin PA, Lledo PM, Vincent JD and Charpak S. (2001) Dendritic glutamate autoreceptors modulate signal processing in rat mitral cells. J Neurophysiol 85:1275-82 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Olfactory bulb main mitral cellDistal basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ). Both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular BAPTA and result from a calcium-dependent release of glutamate (Salin PA et al, 2001 [rat ]189 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main tufted middle cellDistal basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ). Both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular BAPTA and result from a calcium-dependent release of glutamate (Salin PA et al, 2001 [rat ]189 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).

References
14. Petralia RS, Yokotani N and Wenthold RJ. (1994) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J Neurosci 14:667-96.
189. Salin PA, Lledo PM, Vincent JD and Charpak S. (2001) Dendritic glutamate autoreceptors modulate signal processing in rat mitral cells. J Neurophysiol 85:1275-82 [Journal] .
234. Isaacson JS. (1999) Glutamate spillover mediates excitatory transmission in the rat olfactory bulb. Neuron 23:377-84.
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