196. Westenbroek RE, Ahlijanian MK and Catterall WA. (1990) Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons. Nature 347:281-4.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA1 pyramidal cellProximal apical dendriteI L high threshold.Using a monoclonal antibody Westenbroek RE et al, 1990196 showed that the proximal dendrites and somata of hippocampal neurons label for L-type Ca2+ channels and that these channels tend to cluster near the bases of the neural processes. In patch recordings, "HVA-l channels reminiscent of L-type channels were occasionally encountered primarily in the more proximal dendrites" (and in the soma) (Magee JC and Johnston D, 1995 [rat ]140 ). Ca fluorescence imaging shows that application of L-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a significantly greater effect in the proximal dendrites than in more distal dendrites (Christie BR et al, 1995143 ).

References
196. Westenbroek RE, Ahlijanian MK and Catterall WA. (1990) Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons. Nature 347:281-4.
140. Magee JC and Johnston D. (1995) Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. J Physiol 487 ( Pt 1):67-90.
143. Christie BR, Eliot LS, Ito K, Miyakawa H and Johnston D. (1995) Different Ca2+ channels in soma and dendrites of hippocampal pyramidal neurons mediate spike-induced Ca2+ influx. J Neurophysiol 73:2553-7 [Journal] .
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