199. Sanchez-Andres JV and Alkon DL. (1991) Voltage-clamp analysis of the effects of classical conditioning on the hippocampus. J Neurophysiol 65:796-807.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA1 pyramidal cellSomaI M.Cells were voltage-clamped using a single microelectrode, at 23-30 degrees C. M-current resembled that of sympathetic ganglion cells. It was abolished by addition of carbachol, muscarine or bethanechol, as well as by 1 mM barium. It was suggested that activation of cholinergic septal inputs to the hippocampus facilitates repetitive firing of pyramidal cells by turning off the M-conductance, without much change in the resting potential of the cell (Halliwell JV and Adams PR, 1982 [guinea pig ]197 ). It was was blocked by linopirdine in a reversible, concentration-dependent manner (Aiken SP et al, 1995 [rat ]198 ), and by cholinergic agonists in slices (Sanchez-Andres JV and Alkon DL, 1991 [rabbit ]199 ). Serotonin produced a slowly developing and long-lasting suppression of IM leading to depolarization end excitation (Colino A and Halliwell JV, 2004 [rat ]200 ). It was decreased by cannabinoids (Schweitzer P, 2000287 ).

References
197. Halliwell JV and Adams PR. (1982) Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res 250:71-92.
198. Aiken SP, Lampe BJ, Murphy PA and Brown BS. (1995) Reduction of spike frequency adaptation and blockade of M-current in rat CA1 pyramidal neurones by linopirdine (DuP 996), a neurotransmitter release enhancer. Br J Pharmacol 115:1163-8.
199. Sanchez-Andres JV and Alkon DL. (1991) Voltage-clamp analysis of the effects of classical conditioning on the hippocampus. J Neurophysiol 65:796-807.
200. Colino A and Halliwell JV. (2004) Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature 328:73-7.
287. Schweitzer P. (2000) Cannabinoids decrease the K(+) M-current in hippocampal CA1 neurons. J Neurosci 20:51-8.
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