205. Beck H, Steffens R, Elger CE and Heinemann U. (1998) Voltage-dependent Ca2+ currents in epilepsy. Epilepsy Res 32:321-32.

NeuronCompartmentPropertyConnectivityNotes
Dentate gyrus granule cellSomaI L high threshold.Cells acutely dissociated from slices obtained from chronic temporal lobe epilepsy patients displayed a high-voltage activated Ca2+ conductance with a pronounced Ca2+-dependent inactivation (Nagerl UV and Mody I, 1998 [human ]204 ). Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats (Beck H et al, 1998 [human ]205 ).
Dentate gyrus granule cellSomaI N.Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats (Beck H et al, 1998 [human ]205 ).
Dentate gyrus granule cellSomaI T low threshold.Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats (Beck H et al, 1998 [human ]205 ).

References
204. Nagerl UV and Mody I. (1998) Calcium-dependent inactivation of high-threshold calcium currents in human dentate gyrus granule cells. J Physiol 509 ( Pt 1):39-45.
205. Beck H, Steffens R, Elger CE and Heinemann U. (1998) Voltage-dependent Ca2+ currents in epilepsy. Epilepsy Res 32:321-32.
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