207. Beck H, Blümcke I, Kral T, Clusmann H, Schramm J, Wiestler OD, Heinemann U and Elger CE. (1996) Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia 37:892-901.

NeuronCompartmentPropertyConnectivityNotes
Dentate gyrus granule cellSomaI K.Properties of K+ outward currents were investigated in human DG cells from 11 specimens obtained from patients with temporal lobe epilepsy. An IK was observed in all cells. The average current density, the time-dependent decay, and the resting membrane characteristics were not significantly different between patients with and without Ammon Horn Sclerosis. The V1/2(inact) was shifted in a hyperpolarizing direction in AHS (-67.7mV) compared with that in hippocampi not showing AHS (-47.7mV) (Beck H et al, 1996 [human ]207 ). The properties of outward currents were investigated with patch-clamp in acutely isolated rat DGCs at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells (Beck H et al, 1992 [rat ]208 ).
Dentate gyrus granule cellSomaI A.Properties of potassium outward currents were investigated from 11 specimens obtained from patients with temporal lobe epilepsy. An IK but not IA or inwardly rectifying potassium currents, were observed in all cells (Beck H et al, 1996 [human ]207 ). The properties of outward currents were investigated with patch-clamp in acutely isolated cells at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells (Beck H et al, 1992 [rat ]208 ).

References
207. Beck H, Blümcke I, Kral T, Clusmann H, Schramm J, Wiestler OD, Heinemann U and Elger CE. (1996) Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy. Epilepsia 37:892-901.
208. Beck H, Ficker E and Heinemann U. (1992) Properties of two voltage-activated potassium currents in acutely isolated juvenile rat dentate gyrus granule cells. J Neurophysiol 68:2086-99 [Journal] .
_4/20/2018 4:32:03 PM