213. Berger T, Larkum ME and Luscher HR. (2001) High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. J Neurophysiol 85:855-68 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Neocortex V1 pyramidal corticothalamic L6 cellDistal apical dendriteI h.Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma (Stuart G and Spruston N, 1998431 ). The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex V1 pyramidal corticothalamic L6 cellMiddle apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex V1 pyramidal corticothalamic L6 cellProximal apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex V1 pyramidal corticothalamic L6 cellSomaI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex V1 pyramidal corticothalamic L6 cellDistal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat ]213 ).
Neocortex V1 pyramidal corticothalamic L6 cellMiddle basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat ]213 ).
Neocortex V1 pyramidal corticothalamic L6 cellProximal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat ]213 ).
Neocortex M1 pyramidal corticothalamic L6 cellDistal apical dendriteI h.Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma (Stuart G and Spruston N, 1998431 ). The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex M1 pyramidal corticothalamic L6 cellMiddle apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex M1 pyramidal corticothalamic L6 cellProximal apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex M1 pyramidal corticothalamic L6 cellSomaI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat ]213 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 2000214 ).
Neocortex M1 pyramidal corticothalamic L6 cellDistal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat ]213 ).
Neocortex M1 pyramidal corticothalamic L6 cellMiddle basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat ]213 ).
Neocortex M1 pyramidal corticothalamic L6 cellProximal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat ]213 ).

References
431. Stuart G and Spruston N. (1998) Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J Neurosci 18:3501-10.
213. Berger T, Larkum ME and Luscher HR. (2001) High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. J Neurophysiol 85:855-68 [Journal] .
214. Williams SR and Stuart GJ. (2000) Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons. J Neurophysiol 83:3177-82 [Journal] .
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