Hippocampus CA3 pyramidal GLU cell | Middle apical dendrite | I L high threshold | . | In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, L-currents were found in 34% of the patches and found to have single channel conductances of 23-27 pS (Johnston D et al, 19922 ). (Fisher RE et al, 19903 ). Whole cell recording experiments have revealed a sustained, partially nimodipine-sensitve current in steps to -50mV, suggesting that they play a role in CA2+ signalling at low voltages as well as a their classical high voltages (Johnston D et al, 19922 ). It has been suggested that voltage-gated calcium channels play a role in LTP (Johnston D et al, 19922 ). and it has been shown that nimodipine (an L-channel antagonist) prevents certain mossy fiber LTP-types from taking place (Kapur A et al, 19981 ). |
Hippocampus CA3 pyramidal GLU cell | Soma | I L high threshold | . | In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, L-currents were found in 34% of the patches and found to have single channel conductances of 23-27 pS (Johnston et al. 1992; (Fisher RE et al, 19903 ). Whole cell recording experiments have revealed a sustained, partially nimodipine-sensitve current in steps to -50mV, suggesting that they play a role in CA2+ signalling at low voltages as well as a their classical high voltages (Avery RB and Johnston D, 1996 [rat]4 ). It has been suggested that voltage-gated calcium channels play a role in LTP (Johnston et al. 1992), and it has been shown that nimodipine (an L-channel antagonist) prevents certain mossy fiber LTP-types from taking place (Kapur A et al, 19981 ). |