1. Martina M, Mozrzymas JW, Strata F and Cherubini E. (1996) Zinc modulation of bicuculline-sensitive and -insensitive GABA receptors in the developing rat hippocampus. Eur J Neurosci 8:2168-76.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA3 pyramidal GLU cellMiddle apical dendriteGabaACA3 Basket Cell terminals (T)Intracellular recording from organotypic rat hippocampal cultures have shown that approximately 25% of single spikes in CA3 pyramidal neurons are followed by IPSPs at a fixed latency, presumeably a result of feedback inhibition from inhibitory interneurons. The addition of bicuculline (a competitive GABA(A) antagonist) completely abolished these responses, but they were insensitive to CGP35348, a GABA(B) antagonist (Fortunato C et al, 19962 ). There is also evidence that Zn+ can modulate bicuculline-sensitive responses to GABA early in development in rat (studied less than 8 days old)(Martina M et al, 1996 [rat]1 ).
Hippocampus CA3 pyramidal GLU cellSomaGabaACA3 Basket Cell terminals (T)Intracellular recording from organotypic rat hippocampal cultures have shown that approximately 25% of single spikes in CA3 pyramidal neurons are followed by IPSPs at a fixed latency, presumeably a result of feedback inhibition from inhibitory interneurons. The addition of bicuculline (a competitive GABA(A) antagonist) completely abolished these responses, but they were insensitive to CGP35348, a GABA(B) antagonist (Fortunato C et al, 19962 ). There is also evidence that Zn+ can modulate bicuculline-sensitive responses to GABA early in development in rat (studied less than 8 days old)(Martina M et al, 1996 [rat]1 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Martina M, Mozrzymas JW, Strata F and Cherubini E. (1996) Zinc modulation of bicuculline-sensitive and -insensitive GABA receptors in the developing rat hippocampus. Eur J Neurosci 8:2168-76.
2.  Fortunato C, Debanne D, Scanziani M, G√§hwiler BH and Thompson SM. (1996) Functional characterization and modulation of feedback inhibitory circuits in area CA3 of rat hippocampal slice cultures. Eur J Neurosci 8:1758-68.