Neuron | Compartment | Property | Connectivity | Notes |
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Olfactory bulb main interneuron granule MC GABA cell | Soma | GabaA | primary culture | Glycine and GABA elicit concentration-dependent desensitizing currents mediated by chloride. (Trombley PQ and Shepherd GM, 19942 ). Cell-specifc modulation of GABAA receptor- mediated chloride current by dopamine. In interneurons (mainly granule cells), dopamine reduces GABAA Cl- current, via D1 receptor and involves phosphorylation of GABAA receptors by PKA. In mitral cell, dopamine enhances GABA responses via activation of D2 receptors and phosphorylation of GABAA receptors via PKC. (Brünig I et al, 19991 ). |
Olfactory bulb main interneuron granule MC GABA cell | Soma | Dopaminergic Receptor | primary culture | Cell-specifc modulation of GABAA receptor- mediated chloride current by dopamine. In interneurons (mainly granule cells), dopamine reduces GABAA Cl- current, via D1 receptor and involves phosphorylation of GABAA receptors by PKA. In mitral cell, dopamine enhances GABA responses via activation of D2 receptors and phosphorylation of GABAA receptors via PKC. (Brünig I et al, 19991 ). |
Olfactory bulb main interneuron granule TC GABA cell | Soma | GabaA | . | Glycine and GABA elicit concentration-dependent desensitizing currents mediated by chloride. (Trombley PQ and Shepherd GM, 19942 ). Cell-specifc modulation of GABAA receptor- mediated chloride current by dopamine. In interneurons (mainly granule cells), dopamine reduces GABAA Cl- current, via D1 receptor and involves phosphorylation of GABAA receptors by PKA. In mitral cell, dopamine enhances GABA responses via activation of D2 receptors and phosphorylation of GABAA receptors via PKC. (Brünig I et al, 19991 ). |
Olfactory bulb main interneuron granule TC GABA cell | Soma | Dopaminergic Receptor | primary culture | Cell-specifc modulation of GABAA receptor- mediated chloride current by dopamine. In interneurons (mainly granule cells), dopamine reduces GABAA Cl- current, via D1 receptor and involves phosphorylation of GABAA receptors by PKA. In mitral cell, dopamine enhances GABA responses via activation of D2 receptors and phosphorylation of GABAA receptors via PKC. (Brünig I et al, 19991 ). |