1. Sheldon PW and Aghajanian GK. (1991) Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse 9:208-18 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Piriform cortex anterior interneuron deep layer GABA cellDistal equivalent dendrite5-HT2.A subpopulation of interneurons in layer III of the rat piriform cortex are excited by 5-hydroxytryptamine (5-HT) via 5-HT2A receptors and by norepinephrine via alpha 1-adrenoceptors. (Marek GJ and Aghajanian GK, 19962 ). 5-HT excites 5-HT2 receptors in interneurons and 5-HT1C receptors in pyramidal neurons (Sheldon PW and Aghajanian GK, 19911 ). (Sheldon PW and Aghajanian GK, 19903 ). PKC may have a negative feedback role in modulating excitation by 5-HT in piriform cortical interneurons (Marek GJ and Aghajanian GK, 19954 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Sheldon PW and Aghajanian GK. (1991) Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse 9:208-18 [Journal] .
2.  Marek GJ and Aghajanian GK. (1996) Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons. Eur J Pharmacol 305:95-100.
3.  Sheldon PW and Aghajanian GK. (1990) Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron. Brain Res 506:62-9.
4.  Marek GJ and Aghajanian GK. (1995) Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. Synapse 21:123-30 [Journal] .