234. Isaacson JS. (1999) Glutamate spillover mediates excitatory transmission in the rat olfactory bulb. Neuron 23:377-84.

NeuronCompartmentPropertyConnectivityNotes
Olfactory bulb main mitral cellProximal basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main mitral cellDistal basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ). Both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular BAPTA and result from a calcium-dependent release of glutamate (Salin PA et al, 2001 [rat ]189 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main mitral cellMiddle basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main mitral cellMiddle apical dendriteNMDA.Auto-activation from glutamate released by mitral cell secondary dendrites (van den Pol AN, 1995 [rat ]1 ). Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main mitral cellProximal apical dendriteNMDA.Auto-activation from glutamate released by mitral cell secondary dendrites (van den Pol AN, 1995 [rat ]1 ). Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ). The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats (Lowe G, 2003464 ).
Olfactory bulb main mitral cellSomaNMDA.Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ). In an immunocytochemical study in zebrafish all cells resulted in NMDA receptor mediated labelling (Edwards JG and Michel WC, 2003460 ). The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats (Lowe G, 2003464 ).
Olfactory bulb main tufted middle cellDistal basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ). Both ionotropic NMDA and non-NMDA autoreceptors are activated by glutamate released from primary and secondary dendrites. In contrast to non-NMDA autoreceptors, NMDA autoreceptors are almost exclusively located on secondary dendrites and their activation generates a large and sustained self-excitation. Both intracellularly evoked and miniature NMDA-R mediated synaptic potentials are blocked by intracellular BAPTA and result from a calcium-dependent release of glutamate (Salin PA et al, 2001 [rat ]189 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main tufted middle cellMiddle basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main tufted middle cellProximal basal dendriteNMDA.(Petralia RS et al, 1994 [rat ]14 ).Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main tufted middle cellMiddle apical dendriteNMDA.Auto-activation from glutamate released by mitral cell secondary dendrites (van den Pol AN, 1995 [rat ]1 ). Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ).
Olfactory bulb main tufted middle cellProximal apical dendriteNMDA.Auto-activation from glutamate released by mitral cell secondary dendrites (van den Pol AN, 1995 [rat ]1 ). Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ). The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats (Lowe G, 2003464 ).
Olfactory bulb main tufted middle cellSomaNMDA.Paired recordings in slices showed excitatory transmission mediated solely by transmitter spillover between mitral cells. Dendritic glutamate release causes self-excitation via local activation of NMDA receptors, and generates NMDA receptor-mediated responses in neighbouring cells. It is suggested that this simultaneous activation of neighbouring cells by a diffuse action of glutamate provides a mechanism for synchronizing olfactory principal cells (Isaacson JS, 1999234 ). In an immunocytochemical study in zebrafish all cells resulted in NMDA receptor mediated labelling (Edwards JG and Michel WC, 2003460 ).

References
14. Petralia RS, Yokotani N and Wenthold RJ. (1994) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J Neurosci 14:667-96.
234. Isaacson JS. (1999) Glutamate spillover mediates excitatory transmission in the rat olfactory bulb. Neuron 23:377-84.
189. Salin PA, Lledo PM, Vincent JD and Charpak S. (2001) Dendritic glutamate autoreceptors modulate signal processing in rat mitral cells. J Neurophysiol 85:1275-82 [Journal] .
1. van den Pol AN. (1995) Presynaptic metabotropic glutamate receptors in adult and developing neurons: autoexcitation in the olfactory bulb. J Comp Neurol 359:253-71 [Journal] .
464. Lowe G. (2003) Flash photolysis reveals a diversity of ionotropic glutamate receptors on the mitral cell somatodendritic membrane. J Neurophysiol 90:1737-46 [Journal] .
460. Edwards JG and Michel WC. (2003) Pharmacological characterization of ionotropic glutamate receptors in the zebrafish olfactory bulb. Neuroscience 122:1037-47.
_7/22/2018 8:22:45 PM