|Neostriatum spiny direct pathway neuron||Soma||I A||.||The contribution of a fast (IAt), and a slowly (IAs)-inactivating A-currents were studied in slices. The results suggest a role for these currents to define the limits on the depolarized state (Nisenbaum ES and Wilson CJ, 1995237 ). With whole-cell patch clamp, two types of A-current were found in rat neostriatal neurons, one similar to previous descriptions in mammals and a second activated at considerably more depolarized potentials (Surmeier DJ et al, 1989239 ). A slowly inactivating A current has also been studied (Gabel LA and Nisenbaum ES, 1998246 ).
|Neostriatum spiny direct pathway neuron||Soma||I h||.||The contribution of an inwardly rectifying current (IKir) were studied in slices. The results suggest that the hyperpolarized state is determined principally by this current (Nisenbaum ES and Wilson CJ, 1995237 ).|
|Neostriatum spiny direct pathway neuron||Soma||I Potassium||.||A slow, noninactivating current may have a role to define the limits on the depolarized state, and to govern the spike discharge characteristics once the depolarized state has been reached (Nisenbaum ES and Wilson CJ, 1995237 ).
A non-inactivating, Ca-independent, K+ current may limit the amplitude of membrane depolarizations associated with prolonged excursions into the depolarized state (Nisenbaum ES et al, 1996 [rat ]242 ).