241. Hernandez-Lopez S, Bargas J, Surmeier DJ, Reyes A and Galarraga E. (1997) D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance. J Neurosci 17:3334-42.

NeuronCompartmentPropertyConnectivityNotes
Neostriatum spiny direct pathway neuronSomaI L high threshold.Whole-cell voltage-clamp recordings showed that HVA currents were present in at least 95% of neostriatal neurons, but that the majority of them appeared to belong neither to the "L-type" nor the "N-type" classification (Hoehn K et al, 1993 [rat ]236 ). However, recordings in slices showed that D1 receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization, by modulating an L-type Ca2+ conductance (Hernandez-Lopez S et al, 1997241 ).
Neostriatum spiny direct pathway neuronSomaD1.Activation of both D1- and D2-class receptors has been shown to modulate potassium and sodium currents in acutely isolated neostriatal neurons (Surmeier DJ and Kitai ST, 1993238 ).Recordings in slices showed that D1 receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization, by modulating an L-type Ca2+ conductance (Hernandez-Lopez S et al, 1997241 ).

References
236. Hoehn K, Watson TW and MacVicar BA. (1993) Multiple types of calcium channels in acutely isolated rat neostriatal neurons. J Neurosci 13:1244-57.
241. Hernandez-Lopez S, Bargas J, Surmeier DJ, Reyes A and Galarraga E. (1997) D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance. J Neurosci 17:3334-42.
238. Surmeier DJ and Kitai ST. (1993) D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons. Prog Brain Res 99:309-24.
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