262. Pineda JC, Waters RS and Foehring RC. (1998) Specificity in the interaction of HVA Ca2+ channel types with Ca2+-dependent AHPs and firing behavior in neocortical pyramidal neurons. J Neurophysiol 79:2522-34.

NeuronCompartmentPropertyConnectivityNotes
Neocortex V1 pyramidal intratelencephalic L2-6 cellSomaI Calcium.Intracellular recordings suggested different functional consequences for modulation of Ca2+ current subtypes. Based on the effects of specific organic Ca2+ channel blockers the sAHP was found to be coupled to N-, P-, and Q-type currents. P-type currents were coupled to the mAHP (Pineda JC et al, 1998262 ). It has been suggested that the pharmacologically separable components of the HVA current in these neurons do not differ significantly in kinetics (Brown AM et al, 1993 [rat ]285 ). Recordings from acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging found that single action potentials evoke substantial Ca2+ influx in the apical trunk. (Waters J et al, 2003479 ). Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats (Larkum ME et al, 2003481 ).
Neocortex V1 pyramidal intratelencephalic L2-6 cellSomaI L high threshold.It has been suggested that this current is not involved in the generation of AHP but (with other HVA currents) contributes to the inward currents that regulate interspike intervals during repetitive firing (Pineda JC et al, 1998262 ). using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).
Neocortex M1 pyramidal intratelencephalic L2-6 cellSomaI Calcium.Intracellular recordings suggested different functional consequences for modulation of Ca2+ current subtypes. Based on the effects of specific organic Ca2+ channel blockers the sAHP was found to be coupled to N-, P-, and Q-type currents. P-type currents were coupled to the mAHP (Pineda JC et al, 1998262 ). It has been suggested that the pharmacologically separable components of the HVA current in these neurons do not differ significantly in kinetics (Brown AM et al, 1993 [rat ]285 ). Recordings from acute brain slices and in anesthetized rats using whole-cell recordings and Ca2+ imaging found that single action potentials evoke substantial Ca2+ influx in the apical trunk. (Waters J et al, 2003479 ). Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats (Larkum ME et al, 2003481 ).
Neocortex M1 pyramidal intratelencephalic L2-6 cellSomaI L high threshold.It has been suggested that this current is not involved in the generation of AHP but (with other HVA currents) contributes to the inward currents that regulate interspike intervals during repetitive firing (Pineda JC et al, 1998262 ). using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).

References
262. Pineda JC, Waters RS and Foehring RC. (1998) Specificity in the interaction of HVA Ca2+ channel types with Ca2+-dependent AHPs and firing behavior in neocortical pyramidal neurons. J Neurophysiol 79:2522-34.
285. Brown AM, Schwindt PC and Crill WE. (1993) Voltage dependence and activation kinetics of pharmacologically defined components of the high-threshold calcium current in rat neocortical neurons. J Neurophysiol 70:1530-43 [Journal] .
479. Waters J, Larkum M, Sakmann B and Helmchen F. (2003) Supralinear Ca2+ influx into dendritic tufts of layer 2-3 neocortical pyramidal neurons in vitro and in vivo. J Neurosci 23:8558-67.
481. Larkum ME, Watanabe S, Nakamura T, Lasser-Ross N and Ross WN. (2003) Synaptically activated Ca2+ waves in layer 2-3 and layer 5 rat neocortical pyramidal neurons. J Physiol 549:471-88.
480. Sun X, Gu XQ and Haddad GG. (2003) Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons. J Neurosci 23:3639-48.
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