264. Sassoe-Pognetto M and Ottersen OP. (2000) Organization of ionotropic glutamate receptors at dendrodendritic synapses in the rat olfactory bulb. J Neurosci 20:2192-201.

NeuronCompartmentPropertyConnectivityNotes
Olfactory bulb main mitral cellProximal basal dendriteAMPA.(Petralia RS and Wenthold RJ, 1992 [rat ]15 ). With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors (Sassoe-Pognetto M and Ottersen OP, 2000264 ). The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats (Lowe G, 2003464 ).
Olfactory bulb main mitral cellDistal basal dendriteAMPA.(Petralia RS and Wenthold RJ, 1992 [rat ]15 ). With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors (Sassoe-Pognetto M and Ottersen OP, 2000264 ).
Olfactory bulb main mitral cellMiddle basal dendriteAMPA.(Petralia RS and Wenthold RJ, 1992 [rat ]15 ). With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors (Sassoe-Pognetto M and Ottersen OP, 2000264 ).
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteGabaonto mitral cell to exert self inhibition or lateral inhibitionGAD-positive gemmules (spines) of granule cells were observed to form reciprocal dendrodentritic synaptic junctions with mitral cell dentrites which lacked reaction product.(Ribak CE et al, 1977333 ) GABAergic inhibitory synapses onto mitral cells, through dendrodendritic spine synapse: possibly two types: self inhibition and lateral inhibition. (Rall W and Shepherd GM, 196873 ) (Isaacson JS and Strowbridge BW, 1998310 ) Mitral-cell soma-dendrites act as a presynaptic terminal to the granule cell; the circuit is recurrent onto the injected cell; and the inhibitory transmitter is GABA (Jahr CE and Nicoll RA, 1982318 and Shepherd GM ed. Synaptic Organization of the Brain, 1998. p182) GABA release onto mitral: spontaneous and gltamate-evoked. Moreover, activation of muscarinic receptors modulates GABAergic synaptic inputs onto mitral cell.(Castillo PE et al, 1999315 ) Selective localization of GABA receptors at symmetric synapses ( and of gluR at asymmetric synapses.) (Sassoe-Pognetto M and Ottersen OP, 2000264 )
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteAMPAmitral (or tufted) cellAMPA and NMDA receptors are clustered, and colocalized, on granule cells dendritic spines. (Sassoe-Pognetto M and Ottersen OP, 2000264 ) DDI (dendrodendritic inhibition) can be elicited by activation of AMPA receptors, while NMDA receptor activation is not an absolute requirement. DDI is blocked by Cd and toxins to N- and P/Q-type channels. (Isaacson JS, 2001309 )
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteGabamitral (or tufted) cellThere is a selective localization of GABA receptors at symmetric synaptic junctions and of glutamate receptors at asymmetric junctions(Sassoe-Pognetto M and Ottersen OP, 2000264 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteAMPA.AMPA and NMDA receptors are clustered, and colocalized, on granule cells dendritic spines. (Sassoe-Pognetto M and Ottersen OP, 2000264 ) DDI (dendrodendritic inhibition) can be elicited by activation of AMPA receptors, while NMDA receptor activation is not an absolute requirement. DDI is blocked by Cd and toxins to N- and P/Q-type channels. (Isaacson JS, 2001309 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteGaba.There is a selective localization of GABA receptors at symmetric synaptic junctions and of glutamate receptors at asymmetric junctions(Sassoe-Pognetto M and Ottersen OP, 2000264 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteGabaonto tuft cell to exert self inhibition or lateral inhibitionGAD-positive gemmules (spines) of granule cells were observed to form reciprocal dendrodentritic synaptic junctions with mitral cell dentrites which lacked reaction product.(Ribak CE et al, 1977333 ) GABAergic inhibitory synapses onto mitral cells, through dendrodendritic spine synapse: possibly two types: self inhibition and lateral inhibition. (Rall W and Shepherd GM, 196873 ) (Isaacson JS and Strowbridge BW, 1998310 ) Mitral-cell soma-dendrites act as a presynaptic terminal to the granule cell; the circuit is recurrent onto the injected cell; and the inhibitory transmitter is GABA (Jahr CE and Nicoll RA, 1982318 and Shepherd GM ed. Synaptic Organization of the Brain, 1998. p182) GABA release onto mitral: spontaneous and gltamate-evoked. Moreover, activation of muscarinic receptors modulates GABAergic synaptic inputs onto mitral cell.(Castillo PE et al, 1999315 ) Selective localization of GABA receptors at symmetric synapses ( and of gluR at asymmetric synapses.) (Sassoe-Pognetto M and Ottersen OP, 2000264 )
Olfactory bulb main tufted middle cellDistal basal dendriteAMPA.(Petralia RS and Wenthold RJ, 1992 [rat ]15 ). With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors (Sassoe-Pognetto M and Ottersen OP, 2000264 ).
Olfactory bulb main tufted middle cellProximal basal dendriteAMPA.(Petralia RS and Wenthold RJ, 1992 [rat ]15 ). With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors (Sassoe-Pognetto M and Ottersen OP, 2000264 ). The pharmacology and kinetics of glutamate sensitivity of mitral cells was studied using flash photolysis in rats (Lowe G, 2003464 ).
Olfactory bulb main tufted middle cellMiddle basal dendriteAMPA.With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors (Sassoe-Pognetto M and Ottersen OP, 2000264 ).

References
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264. Sassoe-Pognetto M and Ottersen OP. (2000) Organization of ionotropic glutamate receptors at dendrodendritic synapses in the rat olfactory bulb. J Neurosci 20:2192-201.
464. Lowe G. (2003) Flash photolysis reveals a diversity of ionotropic glutamate receptors on the mitral cell somatodendritic membrane. J Neurophysiol 90:1737-46 [Journal] .
333. Ribak CE, Vaughn JE, Saito K, Barber R and Roberts E. (1977) Glutamate decarboxylase localization in neurons of the olfactory bulb. Brain Res 126:1-18.
73. Rall W and Shepherd GM. (1968) Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J Neurophysiol 31:884-915 [Journal] .
310. Isaacson JS and Strowbridge BW. (1998) Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron 20:749-61.
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