284. Wierenga CJ and Wadman WJ. (1999) Miniature inhibitory postsynaptic currents in CA1 pyramidal neurons after kindling epileptogenesis. J Neurophysiol 82:1352-62.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA1 pyramidal cellSomaGabaCA1 Basket Cell terminals (T)The baskets formed by inhibitory basket cells have high concentrations of glutamic acid decarboxylase (GAD), the enzyme that synthesizes GABA (Storm-Mathisen J, 1977141 ). A 40-50% reduction in a small fraction of (peri-) somatic synapses with large or complex postsynaptic structure after kindling has been found. This functionally relevant reduction may be related to the loss of a specific class of interneurons, and could underlie the enhanced seizure susceptibility after kindling epileptogenesis (Wierenga CJ and Wadman WJ, 1999 [rat ]284 ).

References
141. Storm-Mathisen J. (1977) Localization of transmitter candidates in the brain: the hippocampal formation as a model. Prog Neurobiol 8:119-81.
284. Wierenga CJ and Wadman WJ. (1999) Miniature inhibitory postsynaptic currents in CA1 pyramidal neurons after kindling epileptogenesis. J Neurophysiol 82:1352-62.
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