295. Ketelaars SO, Gorter JA, van Vliet EA, Lopes da Silva FH and Wadman WJ. (2001) Sodium currents in isolated rat CA1 pyramidal and dentate granule neurones in the post-status epilepticus model of epilepsy. Neuroscience 105:109-20.

NeuronCompartmentPropertyConnectivityNotes
Dentate gyrus granule cellSomaI Na,t.With whole-cell recordings the properties of a voltage-dependent Na+ currents were investigated in 42 DGC acutely isolated from the resected hippocampus of 20 patients with therapy-refractory temporal lobe epilepsy (TLE) using the whole-cell patch-clamp technique. The kinetic properties contributed to a reduction of the Na+ currents during repetitive stimulation that was more pronounced with higher stimulation frequencies and also showed a dependence on the holding potential (Reckziegel G et al, 1998 [human ]203 ). The kinetic properties of this current were studied using the whole-cell voltage-clamp method in acutely isolated cells. No significant differences were found after induction of status epilepticus (Ketelaars SO et al, 2001295 ).

References
203. Reckziegel G, Beck H, Schramm J, Elger CE and Urban BW. (1998) Electrophysiological characterization of Na+ currents in acutely isolated human hippocampal dentate granule cells. J Physiol 509 ( Pt 1):139-50.
295. Ketelaars SO, Gorter JA, van Vliet EA, Lopes da Silva FH and Wadman WJ. (2001) Sodium currents in isolated rat CA1 pyramidal and dentate granule neurones in the post-status epilepticus model of epilepsy. Neuroscience 105:109-20.
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