300. Frick A, Zieglgansberger W and Dodt HU. (2001) Glutamate receptors form hot spots on apical dendrites of neocortical pyramidal neurons. J Neurophysiol 86:1412-21 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Neocortex V1 pyramidal corticothalamic L6 cellDistal apical dendriteGlutamate-----Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points (Frick A et al, 2001300 ).
Neocortex V1 pyramidal corticothalamic L6 cellMiddle apical dendriteGlutamate-----Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points (Frick A et al, 2001300 ).
Neocortex V1 pyramidal corticothalamic L6 cellProximal apical dendriteGlutamate-----Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points (Frick A et al, 2001300 ).
Neocortex M1 pyramidal corticothalamic L6 cellDistal apical dendriteGlutamate-----Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points (Frick A et al, 2001300 ).
Neocortex M1 pyramidal corticothalamic L6 cellMiddle apical dendriteGlutamate-----Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points (Frick A et al, 2001300 ).
Neocortex M1 pyramidal corticothalamic L6 cellProximal apical dendriteGlutamate-----Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points (Frick A et al, 2001300 ).

References
300. Frick A, Zieglgansberger W and Dodt HU. (2001) Glutamate receptors form hot spots on apical dendrites of neocortical pyramidal neurons. J Neurophysiol 86:1412-21 [Journal] .
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