310. Isaacson JS and Strowbridge BW. (1998) Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron 20:749-61.

NeuronCompartmentPropertyConnectivityNotes
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteGabaonto mitral cell to exert self inhibition or lateral inhibitionGAD-positive gemmules (spines) of granule cells were observed to form reciprocal dendrodentritic synaptic junctions with mitral cell dentrites which lacked reaction product.(Ribak CE et al, 1977333 ) GABAergic inhibitory synapses onto mitral cells, through dendrodendritic spine synapse: possibly two types: self inhibition and lateral inhibition. (Rall W and Shepherd GM, 196873 ) (Isaacson JS and Strowbridge BW, 1998310 ) Mitral-cell soma-dendrites act as a presynaptic terminal to the granule cell; the circuit is recurrent onto the injected cell; and the inhibitory transmitter is GABA (Jahr CE and Nicoll RA, 1982318 and Shepherd GM ed. Synaptic Organization of the Brain, 1998. p182) GABA release onto mitral: spontaneous and gltamate-evoked. Moreover, activation of muscarinic receptors modulates GABAergic synaptic inputs onto mitral cell.(Castillo PE et al, 1999315 ) Selective localization of GABA receptors at symmetric synapses ( and of gluR at asymmetric synapses.) (Sassoe-Pognetto M and Ottersen OP, 2000264 )
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteNMDAfrom mitral cellNMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 1998313 ) NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 1998310 ) Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 2000311 ) Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 2000312 )
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteI p,q.Dendrodendritic inhibition (DDI) between mitral and granule cells relies on N-and P/Q- type calcium channels. Magnitude of DDI is proportional to dendritic calcium influx. (Isaacson JS and Strowbridge BW, 1998310 )
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteI N.Dendrodendritic inhibition between mitral and granule cells involves N-and P/Q- type calcium channels. The magnitude of DDI is proportional to dendritic calcium influx. (Isaacson JS and Strowbridge BW, 1998310 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteNMDA.NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 1998310 ) Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 2000311 ) Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 2000312 ). NMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 1998313 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteGabaonto tuft cell to exert self inhibition or lateral inhibitionGAD-positive gemmules (spines) of granule cells were observed to form reciprocal dendrodentritic synaptic junctions with mitral cell dentrites which lacked reaction product.(Ribak CE et al, 1977333 ) GABAergic inhibitory synapses onto mitral cells, through dendrodendritic spine synapse: possibly two types: self inhibition and lateral inhibition. (Rall W and Shepherd GM, 196873 ) (Isaacson JS and Strowbridge BW, 1998310 ) Mitral-cell soma-dendrites act as a presynaptic terminal to the granule cell; the circuit is recurrent onto the injected cell; and the inhibitory transmitter is GABA (Jahr CE and Nicoll RA, 1982318 and Shepherd GM ed. Synaptic Organization of the Brain, 1998. p182) GABA release onto mitral: spontaneous and gltamate-evoked. Moreover, activation of muscarinic receptors modulates GABAergic synaptic inputs onto mitral cell.(Castillo PE et al, 1999315 ) Selective localization of GABA receptors at symmetric synapses ( and of gluR at asymmetric synapses.) (Sassoe-Pognetto M and Ottersen OP, 2000264 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteI p,q.Dendrodendritic inhibition (DDI) between mitral and granule cells relies on N-and P/Q- type calcium channels. Magnitude of DDI is proportional to dendritic calcium influx. (Isaacson JS and Strowbridge BW, 1998310 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteI N.Dendrodendritic inhibition between mitral and granule cells involves N-and P/Q- type calcium channels. The magnitude of DDI is proportional to dendritic calcium influx. (Isaacson JS and Strowbridge BW, 1998310 )

References
333. Ribak CE, Vaughn JE, Saito K, Barber R and Roberts E. (1977) Glutamate decarboxylase localization in neurons of the olfactory bulb. Brain Res 126:1-18.
73. Rall W and Shepherd GM. (1968) Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. J Neurophysiol 31:884-915 [Journal] .
310. Isaacson JS and Strowbridge BW. (1998) Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron 20:749-61.
318. Jahr CE and Nicoll RA. (1982) An intracellular analysis of dendrodendritic inhibition in the turtle in vitro olfactory bulb. J Physiol 326:213-34.
315. Castillo PE, Carleton A, Vincent JD and Lledo PM. (1999) Multiple and opposing roles of cholinergic transmission in the main olfactory bulb. J Neurosci 19:9180-91.
264. Sassoe-Pognetto M and Ottersen OP. (2000) Organization of ionotropic glutamate receptors at dendrodendritic synapses in the rat olfactory bulb. J Neurosci 20:2192-201.
313. Schoppa NE, Kinzie JM, Sahara Y, Segerson TP and Westbrook GL. (1998) Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors. J Neurosci 18:6790-802.
311. Chen WR, Xiong W and Shepherd GM. (2000) Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron 25:625-33.
312. Halabisky B, Friedman D, Radojicic M and Strowbridge BW. (2000) Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells. J Neurosci 20:5124-34.
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