Neuron | Compartment | Property | Connectivity | Notes |
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Olfactory bulb main interneuron granule MC cell | Distal equivalent dendrite | NMDA | from mitral cell | NMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 1998313 )
NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 1998310 )
Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 2000311 )
Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 2000312 ) |
Olfactory bulb main interneuron granule TC cell | Distal equivalent dendrite | NMDA | . | NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 1998310 ) Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 2000311 ) Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 2000312 ).
NMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 1998313 ) |