313. Schoppa NE, Kinzie JM, Sahara Y, Segerson TP and Westbrook GL. (1998) Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors. J Neurosci 18:6790-802.

NeuronCompartmentPropertyConnectivityNotes
Olfactory bulb main interneuron granule MC cellDistal equivalent dendriteNMDAfrom mitral cellNMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 1998313 ) NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 1998310 ) Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 2000311 ) Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 2000312 )
Olfactory bulb main interneuron granule TC cellDistal equivalent dendriteNMDA.NMDA receptors play a critical role in dendrodendritic inhibition between mitral and granule cells. Moreover, N- and P/Q type calcium channels are involved. (Isaacson JS and Strowbridge BW, 1998310 ) Calcium influx through NMDA receptors can directly trigger presynatic GABA release for local dendrodendritic feedback inhibition. DDI is elicited by photorelease of caged Ca++, with and without Cd++ and Ni++. (Chen WR et al, 2000311 ) Calcium influx through NMDA receptors directly evokes GABA release in granule cells. (Halabisky B et al, 2000312 ). NMDA receptor is required for DDI (dendrodendritic inhibition) since IPSC was completely blocked by AP-5. Ineffectiveness of AMPA receptor-mediated EPSPs to activate the granule cells may be due to their intrinsic membrane properties. (Schoppa NE et al, 1998313 )

References
313. Schoppa NE, Kinzie JM, Sahara Y, Segerson TP and Westbrook GL. (1998) Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors. J Neurosci 18:6790-802.
310. Isaacson JS and Strowbridge BW. (1998) Olfactory reciprocal synapses: dendritic signaling in the CNS. Neuron 20:749-61.
311. Chen WR, Xiong W and Shepherd GM. (2000) Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron 25:625-33.
312. Halabisky B, Friedman D, Radojicic M and Strowbridge BW. (2000) Calcium influx through NMDA receptors directly evokes GABA release in olfactory bulb granule cells. J Neurosci 20:5124-34.
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