|Olfactory cortex anterior interneuron superficial layer||Axon terminal||Gaba||Distal apical dendrites of pyramidal cells||The GABABR1a antibody selectively marked the neuropil in layer Ia, where afferent olfactory fibers and intrinsic GABAergic axons terminate on the distal apical dendrites of pyramidal neurons. GABABR1a may be involved in feedforward synaptic circuits (Princivalle A et al, 2000349 ). Horizontal cells in layer Ia are labelled for GAD and GABA, but not for GABA takeup, suggesting lack of local axon collaterals or high-affinity GABA takeup sites (Haberly LB et al, 1987348 ).|
|Olfactory cortex anterior interneuron deep layer||Axon terminal||Gaba||onto pyramidal neuron||Inhibition of deep neurons (pyramidal and multipolar) by (presumed?) deep layer interneurons involves a fast Chloride and a slow potassium-mediated IPSP (Tseng GF and Haberly LB, 1989350 ). Different GABAergic receptors are localized to specific layers, and may mediate feedforward and feedback inhibitions (Princivalle A et al, 2000349 ).
Cholinergic agonist carbachol caused a significant suppression of inhibitory postsynaptic potentials (IPSPs) in the pyramidal neurons that were induced by stimulation of layer Ib, with a weaker effect on IPSPs induced by stimulation of layer Ia (Patil MM and Hasselmo ME, 1999341 ). Dendritic GABAA-mediated IPSPs act largely independent of somatic IPSPs and may regulate facilitation of MNDA-mediated respnses (Kanter ED et al, 1996356 ).|