365. Wilson CJ, Chang HT and Kitai ST. (1990) Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum. J Neurosci 10:508-19.

NeuronCompartmentPropertyConnectivityNotes
Neostriatum interneuron cholinergic cellSomaI h.Neostriatal cholinergic interneurons fire irregularly but tonically in vivo. The summation of relatively few depolarizing potentials and their temporal sequence are thought to underlie spike triggering and the irregularity of action potential timing, respectively (Wilson CJ et al, 1990365 ) (Bennett BD and Wilson CJ, 1998364 ). In vitro, however, blocade of AMPA, NMDA, GABAA,D1 , D2, muscarinic receptors affect little the firing frequencies and patterns of cholinergic interneurons, indicating that these neurons are endogenously active and generate action potentials in the absence of any synaptic input (Bennett BD and Wilson CJ, 1999363 ). Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I(h)), which together ensured that there was no zero current point in the subthreshold voltage range. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels (Bennett BD et al, 2000361 ).

References
365. Wilson CJ, Chang HT and Kitai ST. (1990) Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum. J Neurosci 10:508-19.
364. Bennett BD and Wilson CJ. (1998) Synaptic regulation of action potential timing in neostriatal cholinergic interneurons. J Neurosci 18:8539-49.
363. Bennett BD and Wilson CJ. (1999) Spontaneous activity of neostriatal cholinergic interneurons in vitro. J Neurosci 19:5586-96.
361. Bennett BD, Callaway JC and Wilson CJ. (2000) Intrinsic membrane properties underlying spontaneous tonic firing in neostriatal cholinergic interneurons. J Neurosci 20:8493-503.
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