1. Korngreen A and Sakmann B. (2000) Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J Physiol 525 Pt 3:621-39.

NeuronCompartmentPropertyConnectivityNotes
Neocortex L5/6 pyramidal GLU cellSomaI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellDistal apical dendriteI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellDistal apical dendriteI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellMiddle apical dendriteI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellMiddle apical dendriteI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellProximal apical dendriteI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellSomaI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex L5/6 pyramidal GLU cellProximal apical dendriteI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellSomaI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellDistal apical dendriteI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellDistal apical dendriteI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellMiddle apical dendriteI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellMiddle apical dendriteI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellProximal apical dendriteI K.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellSomaI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellProximal apical dendriteI A.Types and distribution of voltage-gated K+ channels in the soma and apical dendrites were studied in acute brain slices (Korngreen A and Sakmann B, 20001 ). The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased (Bekkers JM, 2000 [rat]2 ). (Bekkers JM, 2000 [rat]3 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Korngreen A and Sakmann B. (2000) Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J Physiol 525 Pt 3:621-39.
2.  Bekkers JM. (2000) Distribution and activation of voltage-gated potassium channels in cell-attached and outside-out patches from large layer 5 cortical pyramidal neurons of the rat. J Physiol 525 Pt 3:611-20.
3.  Bekkers JM. (2000) Properties of voltage-gated potassium currents in nucleated patches from large layer 5 cortical pyramidal neurons of the rat. J Physiol 525 Pt 3:593-609.