480. Sun X, Gu XQ and Haddad GG. (2003) Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons. J Neurosci 23:3639-48.

NeuronCompartmentPropertyConnectivityNotes
Neocortex V1 pyramidal corticothalamic L6 cellSomaI K,Ca.Dual patch-clamp recordings showed that Ca-activated K+ (BK) channels were not triggered by neuronal action potentials in normal slices and only opened as neuronal responses deteriorated (smaller or absent spikes) and in a spike-independent manner, suggesting that BK channels may activate only in pathological conditions (Kang J et al, 2000 [rat ]220 ). Intracellular recordings from sensorimotor cortex suggested that what activate IKCa persistently would not be calcium but some biochemical modification triggered by NMDA receptor activation (Kitagawa H et al, 2000 [cat ]221 ). Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons (Sun X et al, 2003480 ).
Neocortex V1 pyramidal intratelencephalic L2-6 cellSomaI K,Ca.Intracellular recordings from sensorimotor cortex suggested that what activate IKCa persistently would not be calcium but some biochemical modification triggered by NMDA receptor activation (Kitagawa H et al, 2000 [cat ]221 ). Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons (Sun X et al, 2003480 ).
Neocortex V1 pyramidal intratelencephalic L2-6 cellSomaI L high threshold.It has been suggested that this current is not involved in the generation of AHP but (with other HVA currents) contributes to the inward currents that regulate interspike intervals during repetitive firing (Pineda JC et al, 1998262 ). using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).
Neocortex V1 pyramidal corticothalamic L6 cellSomaI CAN.using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).
Neocortex V1 pyramidal corticothalamic L6 cellSomaI L high threshold.using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).
Neocortex M1 pyramidal corticothalamic L6 cellSomaI K,Ca.Dual patch-clamp recordings showed that Ca-activated K+ (BK) channels were not triggered by neuronal action potentials in normal slices and only opened as neuronal responses deteriorated (smaller or absent spikes) and in a spike-independent manner, suggesting that BK channels may activate only in pathological conditions (Kang J et al, 2000 [rat ]220 ). Intracellular recordings from sensorimotor cortex suggested that what activate IKCa persistently would not be calcium but some biochemical modification triggered by NMDA receptor activation (Kitagawa H et al, 2000 [cat ]221 ). Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons (Sun X et al, 2003480 ).
Neocortex M1 pyramidal corticothalamic L6 cellSomaI CAN.using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).
Neocortex M1 pyramidal corticothalamic L6 cellSomaI L high threshold.using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).
Neocortex M1 pyramidal intratelencephalic L2-6 cellSomaI K,Ca.Intracellular recordings from sensorimotor cortex suggested that what activate IKCa persistently would not be calcium but some biochemical modification triggered by NMDA receptor activation (Kitagawa H et al, 2000 [cat ]221 ). Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons (Sun X et al, 2003480 ).
Neocortex M1 pyramidal intratelencephalic L2-6 cellSomaI L high threshold.It has been suggested that this current is not involved in the generation of AHP but (with other HVA currents) contributes to the inward currents that regulate interspike intervals during repetitive firing (Pineda JC et al, 1998262 ). using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels (Sun X et al, 2003480 ).

References
220. Kang J, Huguenard JR and Prince DA. (2000) Voltage-gated potassium channels activated during action potentials in layer V neocortical pyramidal neurons. J Neurophysiol 83:70-80 [Journal] .
221. Kitagawa H, Nishimura Y, Kumazawa Y, Akamine T and Yamamoto T. (2000) Activity-dependent slow hyperpolarization in cat sensorimotor cortex in vitro. Brain Res 869:69-77.
480. Sun X, Gu XQ and Haddad GG. (2003) Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons. J Neurosci 23:3639-48.
262. Pineda JC, Waters RS and Foehring RC. (1998) Specificity in the interaction of HVA Ca2+ channel types with Ca2+-dependent AHPs and firing behavior in neocortical pyramidal neurons. J Neurophysiol 79:2522-34.
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