1. Lien CC and Jonas P. (2003) Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J Neurosci 23:2058-68.

NeuronCompartmentPropertyConnectivityNotes
Hippocampus CA1 interneuron oriens alveus GABA cellSomaI K.These channels are assembled from subunits of the Kv3 family and are necessary for the fast spiking phenotype of O/A interneurons (Lien CC and Jonas P, 20031 ). Densities and kinetics were measured from patch clamp recordings (Martina M et al, 20002 ). Nucleated patches revealed a fast component highly sensitive to external 4-AP and TEA (~57% of total K+ current) and a slow component that was sensitive to high concentrations of TEA, but insensitive to 4-AP (~25% of total K+ current) (Lien CC et al, 20023 ).
Hippocampus CA3 interneuron oriens alveus GABA cellSomaI K.Densities and kinetics were measured from patch clamp recordings (Martina M et al, 20002 ). Nucleated patches revealed a fast component highly sensitive to external 4-AP and TEA (~57% of total K+ current) and a slow component that was sensitive to high concentrations of TEA, but insensitive to 4-AP (~25% of total K+ current) (Lien CC et al, 20023 ). These channels are assembled from subunits of the Kv3 family and are necessary for the fast spiking phenotype of O/A interneurons (Lien CC and Jonas P, 20031 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Lien CC and Jonas P. (2003) Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J Neurosci 23:2058-68.
2.  Martina M, Vida I and Jonas P. (2000) Distal initiation and active propagation of action potentials in interneuron dendrites. Science 287:295-300.
3.  Lien CC, Martina M, Schultz JH, Ehmke H and Jonas P. (2002) Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol 538:405-19.