577. Zhou FM and Lee CR. (2011) Intrinsic and integrative properties of substantia nigra pars reticulata neurons. Neuroscience 198:69-94 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Substantia nigra pars reticulata principal cellSomaI Na,t.“The transient voltage-gated sodium current is strong and fast in SNr GABA neurons. When a sufficient amount of the classical INaT is activated by subthreshold depolarization induced by TRPC3 channels and INa,p [persistent], the regenerative fast rising phase of the action potential is triggered ” Ding S et al, 2011578 . Reviewed in Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellSomaI Na,p.Depolarizes SNr principle cells. Generated by subset of voltage-gated sodium channels that remain open for extended periods of time. Can contribute to neuronal excitability and pacemaking activities. Atherton JF and Bevan MD, 2005579 Reviewed in Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellSomaI K."SNr GABA neurons express a strong Kv3-like current with fast activation and slow inactivation kinetics that is required for the sustained high frequency firing capability in these neurons" Ding S et al, 2011580 Reviewed in Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellSomaI Calcium.“CaV channels are among the intrinsic membrane channels influencing the excitability of the SNr neuronal membrane. CaV channels have been shown to influence spontaneous activity in these neurons, as well as more complex behaviors such as plateau potential generation burst firing.” Atherton JF and Bevan MD, 2005579 Reviewed in Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellSomaI K,Ca.“Calcium entry through N-type calcium channels (CaV2.2) causes activation of KCa channels that decrease the firing rate and increase the regularity of firing in SNr GABA neurons” Yanovsky Y et al, 2005581 Reviewed in Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellDistal equivalent dendriteDopaminergic Receptor."spontaneously released dopamine from dopamine dendrites induces tonic activation of D1-like receptors and exerts a tonic excitatory influence on SNr GABA neurons" Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellMiddle equivalent dendriteDopaminergic Receptor."spontaneously released dopamine from dopamine dendrites induces tonic activation of D1-like receptors and exerts a tonic excitatory influence on SNr GABA neurons." Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellProximal equivalent dendriteDopaminergic Receptor."spontaneously released dopamine from dopamine dendrites induces tonic activation of D1-like receptors and exerts a tonic excitatory influence on SNr GABA neurons." Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellDistal equivalent dendrite5-HT2Raphe nucleus“Histochemical studies have established that SNr receives dense 5-HT innervation originating from 5-HT neurons in raphe nuclei.” Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellMiddle equivalent dendrite5-HT2Raphe nucleus“Histochemical studies have established that SNr receives dense 5-HT innervation originating from 5-HT neurons in raphe nuclei.” Zhou FM and Lee CR, 2011577
Substantia nigra pars reticulata principal cellProximal equivalent dendrite5-HT2Raphe nucleus“Histochemical studies have established that SNr receives dense 5-HT innervation originating from 5-HT neurons in raphe nuclei.” Zhou FM and Lee CR, 2011577

References
578. Ding S, Wei W and Zhou FM. (2011) Molecular and functional differences in voltage-activated sodium currents between GABA projection neurons and dopamine neurons in the substantia nigra. J Neurophysiol 106:3019-34 [Journal] .
577. Zhou FM and Lee CR. (2011) Intrinsic and integrative properties of substantia nigra pars reticulata neurons. Neuroscience 198:69-94 [Journal] .
579. Atherton JF and Bevan MD. (2005) Ionic mechanisms underlying autonomous action potential generation in the somata and dendrites of GABAergic substantia nigra pars reticulata neurons in vitro. J Neurosci 25:8272-81.
580. Ding S, Matta SG and Zhou FM. (2011) Kv3-like potassium channels are required for sustained high-frequency firing in basal ganglia output neurons. J Neurophysiol 105:554-70 [Journal] .
581. Yanovsky Y, Zhang W and Misgeld U. (2005) Two pathways for the activation of small-conductance potassium channels in neurons of substantia nigra pars reticulata. Neuroscience 136:1027-36 [Journal] .
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