599. Tepper JM, Tecuapetla F, Koós T and Ibáñez-Sandoval O. (2010) Heterogeneity and diversity of striatal GABAergic interneurons. Front Neuroanat 4:150 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Neostriatum interneuron gaba/parvalbumin interneuronSomaI Calcium.“The oscillations and the intermittent firing pattern are Ca2+ or SK channel independent, but are completely eliminated by TTX, suggesting that they are due to an interaction between voltage-gated K+ conductances and a persistent or possibly the inactivating sodium conductance responsible for spike generation.” Bracci E et al, 2003598 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronSomaI K,Ca.“The oscillations and the intermittent firing pattern are Ca2+ or SK channel independent, but are completely eliminated by TTX, suggesting that they are due to an interaction between voltage-gated K+ conductances and a persistent or possibly the inactivating sodium conductance responsible for spike generation.” Bracci E et al, 2003598 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronSomaI N.“The oscillations and the intermittent firing pattern are Ca2+ or SK channel independent, but are completely eliminated by TTX, suggesting that they are due to an interaction between voltage-gated K+ conductances and a persistent or possibly the inactivating sodium conductance responsible for spike generation.” Bracci E et al, 2003598 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronDistal equivalent dendriteDopaminergic Receptorpallidostriatal inputD5 and D2 dopamine receptors induce "depolarization and an increase in input resistance in striatal FSI in brain slices" Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronMiddle equivalent dendriteDopaminergic Receptorpallidostriatal inputD5 and D2 dopamine receptors induce "depolarization and an increase in input resistance in striatal FSI in brain slices" Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronProximal equivalent dendriteDopaminergic Receptorpallidostriatal inputD5 and D2 dopamine receptors induce "depolarization and an increase in input resistance in striatal FSI in brain slices" Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronSomaDopaminergic Receptorpallidostriatal inputD5 and D2 dopamine receptors induce "depolarization and an increase in input resistance in striatal FSI in brain slices" Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronDistal equivalent dendriteNicotinicstriatal input While nicotinic and muscarinic acetylcholine receptors exist in FSI-SPN synapses, only the nicotinic receptors are postsynaptic. Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronMiddle equivalent dendriteNicotinicstriatal input While nicotinic and muscarinic acetylcholine receptors exist in FSI-SPN synapses, only the nicotinic receptors are postsynaptic. Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronProximal equivalent dendriteNicotinicstriatal input While nicotinic and muscarinic acetylcholine receptors exist in FSI-SPN synapses, only the nicotinic receptors are postsynaptic. Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronSomaNicotinicstriatal input While nicotinic and muscarinic acetylcholine receptors exist in FSI-SPN synapses, only the nicotinic receptors are postsynaptic. Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronDistal equivalent dendriteGabapallidostriatal inputFSIs “have GABAergic inputs originating from the GP. The pallidostriatal inputs are largely selective for FSIs (Bevan et al., 1998) and in vivo, increased firing of FSI during choice selection in a simple discrimination task coincide with a decrease in firing of GP neurons .” Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronMiddle equivalent dendriteGabapallidostriatal inputFSIs “have GABAergic inputs originating from the GP. The pallidostriatal inputs are largely selective for FSIs (Bevan et al., 1998) and in vivo, increased firing of FSI during choice selection in a simple discrimination task coincide with a decrease in firing of GP neurons .” Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronProximal equivalent dendriteGabapallidostriatal inputFSIs “have GABAergic inputs originating from the GP. The pallidostriatal inputs are largely selective for FSIs (Bevan et al., 1998) and in vivo, increased firing of FSI during choice selection in a simple discrimination task coincide with a decrease in firing of GP neurons .” Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronSomaGabapallidostriatal inputFSIs “have GABAergic inputs originating from the GP. The pallidostriatal inputs are largely selective for FSIs (Bevan et al., 1998) and in vivo, increased firing of FSI during choice selection in a simple discrimination task coincide with a decrease in firing of GP neurons .” Tepper JM et al, 2010599
Neostriatum interneuron gaba/parvalbumin interneuronAxon terminalGabastriatal connections to SPNs“Striatal FSIs make [GABAergic] synapses onto both direct and indirect path- way SPN. The biophysical properties of the synaptic contacts do not differ and exhibit short-term depression. Further, single FSI often make synapses with both types of SPN” Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronSomaI T low threshold."The most characteristic attributes of these neurons were the presence of a low threshold Ca2+ spike." Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronDistal equivalent dendriteDopaminergic ReceptorCortical input“PLTS interneurons receive numerous synaptic contacts on their proximal dendrites from both cholinergic and dopaminergic axons, as well as onto their distal dendrites, which receive asymmetric synaptic inputs from the cortex.” Kubota Y et al, 1988601 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronProximal equivalent dendriteDopaminergic Receptornigrostriatal input“PLTS interneurons receive numerous synaptic contacts on their proximal dendrites from both cholinergic and dopaminergic axons, as well as onto their distal dendrites, which receive asymmetric synaptic inputs from the cortex.” Kubota Y et al, 1988601 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronSomaDopaminergic Receptornigrostriatal input“PLTS interneurons receive numerous synaptic contacts on their proximal dendrites from both cholinergic and dopaminergic axons, as well as onto their distal dendrites, which receive asymmetric synaptic inputs from the cortex.” Kubota Y et al, 1988601 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronProximal equivalent dendriteCholinergic Receptorsnigrostriatal input“PLTS interneurons receive numerous synaptic contacts on their proximal dendrites from both cholinergic and dopaminergic axons, as well as onto their distal dendrites, which receive asymmetric synaptic inputs from the cortex.” Vuillet J et al, 1992602 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronSomaCholinergic Receptorsnigrostriatal input“PLTS interneurons receive numerous synaptic contacts on their proximal dendrites from both cholinergic and dopaminergic axons, as well as onto their distal dendrites, which receive asymmetric synaptic inputs from the cortex.” Vuillet J et al, 1992602 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronDistal equivalent dendriteCholinergic ReceptorsCortical input“PLTS interneurons receive numerous synaptic contacts on their proximal dendrites from both cholinergic and dopaminergic axons, as well as onto their distal dendrites, which receive asymmetric synaptic inputs from the cortex.” Vuillet J et al, 1992602 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronDistal equivalent dendriteGabapallidostriatal input“GABAergic synaptic inputs originating from the globus pallidus were also demonstrated ultrastructurally using juxtacellular labeling and NOS immunocytochemistry.” Bevan MD et al, 1998603 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronMiddle equivalent dendriteGabapallidostriatal input“GABAergic synaptic inputs originating from the globus pallidus were also demonstrated ultrastructurally using juxtacellular labeling and NOS immunocytochemistry.” Bevan MD et al, 1998603 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronProximal equivalent dendriteGabapallidostriatal input“GABAergic synaptic inputs originating from the globus pallidus were also demonstrated ultrastructurally using juxtacellular labeling and NOS immunocytochemistry.” Bevan MD et al, 1998603 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronDistal equivalent dendriteNMDAweak cortical input“AMPA and NMDA receptor mediated cortical glutamatergic inputs that were relatively weak compared to the inputs of SPNs and GABAA receptor mediated inhibitory inputs comparable to those of SPNs.” Partridge JG et al, 2009604 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronMiddle equivalent dendriteNMDAweak cortical input“AMPA and NMDA receptor mediated cortical glutamatergic inputs that were relatively weak compared to the inputs of SPNs and GABAA receptor mediated inhibitory inputs comparable to those of SPNs.” Partridge JG et al, 2009604 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronProximal equivalent dendriteNMDAweak cortical input“AMPA and NMDA receptor mediated cortical glutamatergic inputs that were relatively weak compared to the inputs of SPNs and GABAA receptor mediated inhibitory inputs comparable to those of SPNs.” Partridge JG et al, 2009604 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronDistal equivalent dendriteAMPAweak cortical input“AMPA and NMDA receptor mediated cortical glutamatergic inputs that were relatively weak compared to the inputs of SPNs and GABAA receptor mediated inhibitory inputs comparable to those of SPNs.” Partridge JG et al, 2009604 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronMiddle equivalent dendriteAMPAweak cortical input“AMPA and NMDA receptor mediated cortical glutamatergic inputs that were relatively weak compared to the inputs of SPNs and GABAA receptor mediated inhibitory inputs comparable to those of SPNs.” Partridge JG et al, 2009604 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronProximal equivalent dendriteAMPAweak cortical input“AMPA and NMDA receptor mediated cortical glutamatergic inputs that were relatively weak compared to the inputs of SPNs and GABAA receptor mediated inhibitory inputs comparable to those of SPNs.” Partridge JG et al, 2009604 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronAxon terminalGabastriatal connections to SPNs“PLTS interneurons were found to evoke only sparse and relatively weak GABAergic IPSCs in SPNs.” Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronAxon terminalSomatostatinstriatal connections to SPNs“Perhaps the principal function of these neurons is to release SOM, NOS, and/or NPY, all of which could exert slower neuromodulatory effects on their postsynaptic targets rather than fast synaptic effects. For example, SOM has been shown to exert a potent presynaptic inhibition on GABA release at SPN–SPN synapses.” Lopez-Huerta VG et al, 2008605 Reviewed in Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronAxon terminalNOpossible“Perhaps the principal function of these neurons is to release SOM, NOS, and/or NPY, all of which could exert slower neuromodulatory effects on their postsynaptic targets rather than fast synaptic effects. For example, SOM has been shown to exert a potent presynaptic inhibition on GABA release at SPN–SPN synapses.” Tepper JM et al, 2010599
Neostriatum interneuron SOM/NOS interneuronAxon terminalneuropeptide Ypossible“Perhaps the principal function of these neurons is to release SOM, NOS, and/or NPY, all of which could exert slower neuromodulatory effects on their postsynaptic targets rather than fast synaptic effects. For example, SOM has been shown to exert a potent presynaptic inhibition on GABA release at SPN–SPN synapses.” Tepper JM et al, 2010599

References
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599. Tepper JM, Tecuapetla F, Koós T and Ibáñez-Sandoval O. (2010) Heterogeneity and diversity of striatal GABAergic interneurons. Front Neuroanat 4:150 [Journal] .
601. Kubota Y, Inagaki S, Kito S, Shimada S, Okayama T, Hatanaka H, Pelletier G, Takagi H and Tohyama M. (1988) Neuropeptide Y-immunoreactive neurons receive synaptic inputs from dopaminergic axon terminals in the rat neostriatum. Brain Res 458:389-93.
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