| Neuron | Compartment | Property | Connectivity | Notes |
|---|
| Neocortex L5/6 pyramidal GLU cell | Distal apical dendrite | I h | . | Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma (Stuart G and Spruston N, 19982 ). The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex L5/6 pyramidal GLU cell | Middle apical dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex L5/6 pyramidal GLU cell | Proximal apical dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex L5/6 pyramidal GLU cell | Soma | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex L5/6 pyramidal GLU cell | Distal basal dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ). |
| Neocortex L5/6 pyramidal GLU cell | Middle basal dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ). |
| Neocortex L5/6 pyramidal GLU cell | Proximal basal dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Distal apical dendrite | I h | . | Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma (Stuart G and Spruston N, 19982 ). The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Middle apical dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Proximal apical dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Soma | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Distal basal dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Middle basal dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ). |
| Neocortex M1 L6 pyramidal corticothalamic GLU cell | Proximal basal dendrite | I h | . | The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ). |
