1. Berger T, Larkum ME and Lüscher HR. (2001) High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. J Neurophysiol 85:855-68 [Journal] .

NeuronCompartmentPropertyConnectivityNotes
Neocortex L5/6 pyramidal GLU cellDistal apical dendriteI h.Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma (Stuart G and Spruston N, 19982 ). The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex L5/6 pyramidal GLU cellMiddle apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex L5/6 pyramidal GLU cellProximal apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex L5/6 pyramidal GLU cellSomaI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex L5/6 pyramidal GLU cellDistal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ).
Neocortex L5/6 pyramidal GLU cellMiddle basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ).
Neocortex L5/6 pyramidal GLU cellProximal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellDistal apical dendriteI h.Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma (Stuart G and Spruston N, 19982 ). The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellMiddle apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellProximal apical dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellSomaI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite (Berger T et al, 2001 [rat]1 ). A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course (Williams SR and Stuart GJ, 20003 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellDistal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellMiddle basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ).
Neocortex M1 L6 pyramidal corticothalamic GLU cellProximal basal dendriteI h.The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance (Berger T et al, 2001 [rat]1 ).

Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Berger T, Larkum ME and Lüscher HR. (2001) High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. J Neurophysiol 85:855-68 [Journal] .
2.  Stuart G and Spruston N. (1998) Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. J Neurosci 18:3501-10 [Journal] .
3.  Williams SR and Stuart GJ. (2000) Site independence of EPSP time course is mediated by dendritic I(h) in neocortical pyramidal neurons. J Neurophysiol 83:3177-82 [Journal] .