Models that contain the Model Concept : Timothy Syndrome

(A disease caused by a spontaneous mutation in the Cav1.2 channel gene. The patients have irregular heart beats and webbing (skin between) the fingers and toes, intermitent low blood sugar, autism, and immune system depression.)
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    Models   Description
1.  Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)
From Zhu and Clancy: "... Here we employ theoretical simulations to examine the effects of a Timothy Syndrome (TS) mutation in the L-type Ca2+ channel on cardiac dynamics over multiple scales, from a gene mutation to protein, cell, tissue, and finally the ECG, to connect a defective Ca2+ channel to arrhythmia susceptibility. ..."

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