Models that contain the Implementer : Wang, Yujiang [ at]

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    Models   Description
1.  A bistable model of Spike-Wave seizure and background activity (Taylor et al. 2014)
This is a four-variable model (in the Amari formalism) of bistable Spike-Wave seizure dynamics and background activity (fixed point). The published code is the deterministic version of the model in the related publication. This model can be used to investigate seizure abatement using stimulation.
2.  A cortical sheet mesoscopic model for investigating focal seizure onset dynamics (Wang et al. 2014)
The model uses realistically coupled, discretised, Wilson-Cowan units to describe the spatio-temporal activity of a cortical sheet. This model has been used the investigate the dynamic onset mechanisms of focal seizures.
3.  Mechanisms underlying different onset patterns of focal seizures (Wang Y et al 2017)
"Focal seizures are episodes of pathological brain activity that appear to arise from a localised area of the brain. The onset patterns of focal seizure activity have been studied intensively, and they have largely been distinguished into two types { low amplitude fast oscillations (LAF), or high amplitude spikes (HAS). Here we explore whether these two patterns arise from fundamentally different mechanisms. Here, we use a previously established computational model of neocortical tissue, and validate it as an adequate model using clinical recordings of focal seizures. We then reproduce the two onset patterns in their most defining properties and investigate the possible mechanisms underlying the different focal seizure onset patterns in the model. ..."

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