| | Models | Description |
| 1. |
A fast model of voltage-dependent NMDA Receptors (Moradi et al. 2013)
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These are two or triple-exponential models of the voltage-dependent NMDA receptors. Conductance of these receptors increase voltage-dependently with a "Hodgkin and Huxley-type" gating style that is also depending on glutamate-binding. Time course of the gating of these receptors in response to glutamate are also changing voltage-dependently. Temperature sensitivity and desensitization of these receptor are also taken into account.
Three previous kinetic models that are able to simulate the voltage-dependence of the NMDARs are also imported to the NMODL. These models are not temperature sensitive.
These models are compatible with the "event delivery system" of NEURON. Parameters that are reported in our paper are applicable to CA1 pyramidal cell dendrites. |
| 2. |
Learning intrinsic excitability in Medium Spiny Neurons (Scheler 2014)
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"We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way.
We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parameterization of individual ion channels on the neuronal membrane potential-curent relationship (activation function).
We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions.
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| 3. |
NMDA receptor saturation (Chen et al 2001)
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Experiments and modeling reported in the paper Chen N, Ren J, Raymond LA, and Murphy T (2001) support the hypothesis that glutamate has a relatively lower potency at NMDARs than previously thought from agonist application under equilibrium conditions. Further information and reprint requests are available from Dr T.H. Murphy thmurphy at interchange.ubc.ca |
| 4. |
STDP and NMDAR Subunits (Gerkin et al. 2007)
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The paper argues for competing roles of NR2A- and NR2B-containing NMDARs in spike-timing-dependent plasticity. This simple dynamical model recapitulates the results of STDP experiments involving selective blockers of NR2A- and NR2B-containing NMDARs, for which the stimuli are pre- and postsynaptic spikes in varying combinations. Experiments were done using paired recordings from glutamatergic neurons in rat hippocampal cultures. This model focuses on the dynamics of the putative potentiation and depression modules themselves, and their interaction For detailed dynamics involving NMDARs and Ca2+ transients, see Rubin et al., J. Neurophys., 2005. |
