| | Models | Description |
| 1. |
Circadian clock model in mammals (PK/PD model) (Kim & Forger 2013)
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A systems pharmacology model of the mammalian circadian clock including PF-670462 (CK1d/e inhibitor). |
| 2. |
Global structure, robustness, and modulation of neuronal models (Goldman et al. 2001)
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"The electrical characteristics of many neurons are remarkably
robust in the face of changing internal and external conditions.
At the same time, neurons can be highly sensitive to neuromodulators.
We find correlates of this dual robustness and
sensitivity in a global analysis of the structure of a
conductance-based model neuron.
..." |
| 3. |
GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)
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Phase response analysis of a GP neuron model showing type I PRCs for somatic inputs and type II PRCs for dendritic excitation. Analysis of intrinsic currents underlying type II dendritic PRCs. |
| 4. |
Phase oscillator models for lamprey central pattern generators (Varkonyi et al. 2008)
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In our paper, Varkonyi et al. 2008, we derive phase oscillator models for the lamprey central pattern generator from two biophysically based segmental models. We
study intersegmental coordination and show how these models can provide stable intersegmental phase lags observed in real animals.
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| 5. |
Phase response curve of a globus pallidal neuron (Fujita et al. 2011)
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We investigated how changes in ionic conductances alter the phase response curve (PRC) of a globus pallidal (GP) neuron and stability of a synchronous activity of a GP network, using a single-compartmental conductance-based neuron model. The results showed the PRC and the stability were influenced by changes in the persistent sodium current, the Kv3 potassium, the M-type potassium and the calcium-dependent potassium current. |
| 6. |
Phase response curves firing rate dependency of rat purkinje neurons in vitro (Couto et al 2015)
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NEURON implementation of stochastic gating in the Khaliq-Raman Purkinje cell model.
NEURON implementation of the De Schutter and Bower model of a Purkinje Cell.
Matlab scripts to compute the Phase Response Curve (PRC).
LCG configuration files to experimentally determine the PRC.
Integrate and Fire models (leaky and non-leaky) implemented in BRIAN to see the influence of the PRC in a network of unconnected neurons receiving sparse common input. |
| 7. |
Purkinje neuron network (Zang et al. 2020)
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Both spike rate and timing can transmit information in the brain. Phase response curves (PRCs) quantify how a neuron transforms input to output by spike timing. PRCs exhibit strong firing-rate adaptation, but its mechanism and relevance for network output are poorly understood. Using our Purkinje cell (PC) model we demonstrate that the rate adaptation is caused by rate-dependent subthreshold membrane potentials efficiently regulating the activation of Na+ channels. Then we use a realistic PC network model to examine how rate-dependent responses synchronize spikes in the scenario of reciprocal inhibition-caused high-frequency oscillations. The changes in PRC cause oscillations and spike correlations only at high firing rates. The causal role of the PRC is confirmed using a simpler coupled oscillator network model. This mechanism enables transient oscillations between fast-spiking neurons that thereby form PC assemblies. Our work demonstrates that rate adaptation of PRCs can spatio-temporally organize the PC input to cerebellar nuclei. |
| 8. |
Role of active dendrites in rhythmically-firing neurons (Goldberg et al 2006)
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"The responsiveness of rhythmically-firing neurons to synaptic inputs is characterized by their phase response curve (PRC), which relates how weak somatic perturbations affect the timing of the next action potential. The shape of the somatic PRC is an important determinant of collective network dynamics. Here we study theoretically and experimentally the impact of distally-located synapses and dendritic nonlinearities on the synchronization properties of rhythmically firing neurons. Combining the theories of quasi-active cables and phase-coupled oscillators we derive an approximation for the dendritic responsiveness, captured by the neuron's dendritic PRC (dPRC). This closed-form expression indicates that the dPRCs are linearly-filtered versions of the somatic PRC, and that the filter characteristics are determined by the passive and active properties of the dendrite. ... collective dynamics can be qualitatively different depending on the location of the synapse, the neuronal firing rates and the dendritic nonlinearities." See paper for more and details. |
