| Models | Description |
1. |
A bistable model of Spike-Wave seizure and background activity (Taylor et al. 2014)
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This is a four-variable model (in the Amari formalism) of bistable Spike-Wave seizure dynamics and background activity (fixed point). The published code is the deterministic version of the model in the related publication.
This model can be used to investigate seizure abatement using stimulation. |
2. |
Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)
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Transcranial magnetic stimulation (TMS) is a widely applied tool for probing cognitive function in humans and is one of the best tools for clinical treatments and interfering with cognitive tasks. Surprisingly, while TMS has been commercially available for decades, the cellular mechanisms underlying magnetic stimulation remain unclear. Here we investigate these mechanisms using compartmental modeling. We generated a numerical scheme allowing simulation of the physiological response to magnetic stimulation of neurons with arbitrary morphologies and active properties. Computational experiments using this scheme suggested that TMS affects neurons in the central nervous system (CNS) primarily by somatic stimulation. |
3. |
Phase-locking analysis with transcranial magneto-acoustical stimulation (Yuan et al 2017)
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"Transcranial magneto-acoustical stimulation (TMAS) uses ultrasonic waves and a static magnetic field to generate electric current in nerve tissues for the purpose of modulating neuronal activities. It has the advantage of high spatial resolution and penetration depth. Neuronal firing rhythms carry and transmit nerve information in neural systems. In this study, we investigated the phase-locking characteristics of neuronal firing rhythms with TMAS based on the Hodgkin-Huxley neuron model. The simulation results indicate that the modulation frequency of ultrasound can affect the phase-locking behaviors. The results of this study may help us to explain the potential firing mechanism of TMAS." |