| || Models ||Description|
Analytical modelling of temperature effects on an AMPA-type synapse (Kufel & Wojcik 2018)
||This code was used in the construction of the model developed in the paper. It is a modified version of the simulation developed by Postlethwaite et al. 2007 - for details of modifications refer to the main body of Kufel & Wojcik (2018).
Dynamics of sleep oscillations coupled to brain temperature on multiple scales (Csernai et al 2019)
||"Every form of neural activity depends on temperature, yet its
relationship to brain rhythms is poorly understood. In this work we
examined how sleep spindles are influenced by changing brain
temperatures and how brain temperature is influenced by sleep
oscillations. We employed a novel thermoelectrode designed for
measuring temperature while recording neural activity. We found that
spindle frequency is positively correlated and duration negatively
correlated with brain temperature. Local heating of the thalamus
replicated the temperature dependence of spindle parameters in the
heated area only, suggesting biophysical rather than global modulatory
mechanisms, a finding also supported by a thalamic network
model. Finally, we show that switches between oscillatory states also
influence brain temperature on a shorter and smaller scale. Epochs of
paradoxical sleep as well as the infra-slow oscillation were
associated with brain temperature fluctuations below 0.2°C. Our
results highlight that brain temperature is massively intertwined with
sleep oscillations on various time scales."
Temperature-Dependent Pyloric Pacemaker Kernel (Caplan JS et al., 2014)
||"... Here we demonstrate
that biophysical models of channel noise can give rise to two kinds of
recently discovered stochastic facilitation effects in a
Hodgkin-Huxley-like model of auditory brainstem neurons. The first,
known as slope-based stochastic resonance (SBSR), enables phasic
neurons to emit action potentials that can encode the slope of inputs
that vary slowly relative to key time constants in the model. The
second, known as inverse stochastic resonance (ISR), occurs in
tonically firing neurons when small levels of noise inhibit tonic
firing and replace it with burstlike dynamics.
... our results show that possible
associated computational benefits may occur due to channel noise in
neurons of the auditory brainstem.
TRPM8-dependent dynamic response in cold thermoreceptors (Olivares et al. 2015)
||This model reproduces the dynamic response of cold thermoreceptors, transiently changing the firing rate upon heating or cooling. It also displays the 'static' or adapted firing patterns observed in these receptors.