||" ... we employ a
novel reduction algorithm to produce a 2 compartment model of the cerebellar Purkinje
neuron from a previously published, 1089 compartment model. It runs more than 400 times
faster and retains the electrical behavior of the full model. So, it is more suitable for inclusion
in large network models, where computational power is a limiting issue. We show the utility
of this reduced model by demonstrating that it can replicate the full model’s response to
alcohol, which can in turn reproduce experimental recordings from Purkinje neurons
following alcohol application.