Models that contain the Implementer : Lindroos, Robert [robert.lindroos at]

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    Models   Description
1.  Library of biophysically detailed striatal projection neurons (Lindroos and Hellgren Kotaleski 2020)
Library of compartmentalized models used to investigate dendritic integration in striatal projection neurons under neuromodulation.
2.  Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)
We are investigating how dopaminergic modulation of single channels can be combined to make the D1R possitive MSN more excitable. We also connect multiple channels to substrates of a dopamine induced subcellular cascade to highlight that the classical pathway is too slow to explain DA induced kinetics in the subsecond range (Howe and Dombeck, 2016. doi: 10.1038/nature18942)

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