Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

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Accession:102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Leech S cell;
Channel(s): I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s):
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
/
leechSCell
readme.txt
ADP.m *
ADP.vdg *
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
fAHP.m *
fAHP.vdg *
Kdr.m *
Kdr.vdg *
leak.vdg
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf *
netwfile *
ousgrf.def *
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn *
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn *
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn *
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
                            
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		>>    MODELE NAME: neu		>>
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>------------------------------->--------------------------------------->
   THRESHOLD:	-35.0     	> Threshold for transmitter release	>
>------------------------------->--------------------------------------->
   SPIKDUR:	0.003     	> Spike duration. If equal 0 then	>
				>	actual time when presynaptic	>
				>	neuronis above threshold will	>
				>	be measured			>
>------------------------------->--------------------------------------->
   VMINIT:	-48.0     	> Initial value of membrane potential.	>
>------------------------------->--------------------------------------->
   CM:		0.001     	> Membrane capacitance.			>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   MEM_AREA:        		>     Membrane Area options		>
>------------------------------->--------------------------------------->
>	0			>     do not use membrane area		>
>------------------------------->--------------------------------------->
>	1			>     specify membrane area directly	>
>	5.0             >S<     >     um2				>
>------------------------------->--------------------------------------->
	2			>     sphere				>
	10.0            >D<     >     um, diameter			>
	1.0             >C<     >     invagination factor		>
>------------------------------->--------------------------------------->
>	3			>     cylinder				>
>	3.0             >D<     >     diameter				>
>	30.0            >L<     >     um, length			>
>	0		>n<     >     number of ends closed		>
>	1.0             >C<     >     invagination factor		>
>------------------------------->--------------------------------------->
>	membrane area is	>     0.0000031416    cm*cm		>
>------------------------------->--------------------------------------->


>------------------------------->------------------------------->
   CONDUCTANCES:		>	List of Conductances	>
>------------------------------->------------------------------->
	ADP			>	Name of conductance	>
	ADP.vdg			>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	KDR			>	Name of conductance	>
	Kdr.vdg			>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	mAHP			>	Name of conductance	>
	mAHP.vdg		>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	Ca			>	Name of conductance	>
	Ca.vdg			>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	leak			>	Name of conductance	>
	leak.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	Na			>	Name of conductance	>
	Na.vdg			>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	fAHP			>	Name of conductance	>
	fAHP.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	END			>				>
>------------------------------->------------------------------->


>------------------------------->------------------------------->
  LIST_ION:			>	List of Ion pools	>
>------------------------------->------------------------------->
	Ca			>	Name of Ion		>
	Ca.ion			>	File Name		>
	blue			>	Color			>
>------------------------------->------------------------------->
	END			>				>
>------------------------------->------------------------------->


>------------------------------->--------------------------------------->
  CURRENT_TO_ION:		>	List of current contributing	>
				>		to ion pools		>
>------------------------------->--------------------------------------->
	Ca			>	Name of Conductance		>
	Ca			>	Name of Ion			>
	blue			>	Color				>
>------------------------------->--------------------------------------->
	END			>					>
>------------------------------->--------------------------------------->


>------------------------------->--------------------------------------->
  COND_BY_ION:			>	Regulation of V-dep		>
				>	conductances by ion pools	>
>------------------------------->--------------------------------------->
	mAHP			>	Name of Conductance		>
	Ca			>	Name of Ion			>
	Ca.fBR			>	File Name			>
	blue			>	Color				>
>------------------------------->--------------------------------------->
	fAHP			>	Name of Conductance		>
	Ca			>	Name of Ion			>
	Ca.fBR			>	File Name			>
	blue			>	Color				>
>------------------------------->--------------------------------------->
	END			>					>
>------------------------------->--------------------------------------->


END

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