Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

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Accession:102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Leech S cell;
Channel(s): I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s):
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
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leechSCell
readme.txt
ADP.m *
ADP.vdg *
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
fAHP.m *
fAHP.vdg *
Kdr.m *
Kdr.vdg *
leak.vdg
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf *
netwfile *
ousgrf.def *
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn *
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn *
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn *
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
                            
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		>>    modules name: vdg		>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
Ivd:		> 	Current due to a voltage-dependent conductance	>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

>------------------------------->--------------------------------------->
>				>		p			>
>	1			>	G= g x A x B 		(1)	>
>	model.A		>A<	>					>
>	model.B		>B<	>					>
>	0.00 		>g<	>					>
>	1 		>P<	>	Ivd = G x (V -E)		>
>	0 		>E<	>					>
>				>					>
>------------------------------->--------------------------------------->
>				>		p			>
>	2			>	Ivd= g x m x h 		(2)	>
>	model.m		>m<	>					>
>	model.h		>h<	>					>
>	0.00 		>g<	>					>
>	1 		>P<	>	Ivd = G x (V -E)		>
>	0 		>E<	>					>
>				>					>
>------------------------------->--------------------------------------->
>				>		p			>
>	3			>	G= g x A		(3)	>
>	model.A		>A<	>					>
>	0.00 		>g<	>					>
>	1 		>P<	>	Ivd = G x (V -E)		>
>	0 		>E<	>					>
>				>					>
>------------------------------->--------------------------------------->
>				>		p			>
>	4			>	Ivd= g x m 		(4)	>
>	model.m		>m<	>					>
>	0.00 		>g<	>					>
>	1 		>P<	>	Ivd = G x (V -E)		>
>	0 		>E<	>					>
>				>					>
>------------------------------->--------------------------------------->
				>					>
	5			>	Ivd = G x (V -E)	(5)	>
	0.5		>.3 g<	        >					>
	-47.0		>-49.4 E<		>					>
				>					>
>------------------------------->--------------------------------------->

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