Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

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Accession:102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Leech S cell;
Channel(s): I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s):
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
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leechSCell
readme.txt
ADP.m *
ADP.vdg *
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
fAHP.m *
fAHP.vdg *
Kdr.m *
Kdr.vdg *
leak.vdg
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf *
netwfile *
ousgrf.def *
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn *
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn *
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn *
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
                            
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>   modules name: smu          >>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


>----------------------->------------------------------->
  LOGICAL_NAME:         >       Name of Network         >
>.......................>...............................>
        SCell           > The name of the network       >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TIMING:               > Timing information in seconds >
>.......................>...............................>
        0.0000000000    > What value to assign to the   >
                        > variable 'time' at time=0     >
>.......................>...............................>
        0.5000000000    > When to stop the simulation   >
>.......................>...............................>
        0.0000100000    > Step size (h)                 >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ON_LINE_GRAPH:        >       On-line graph           >
>.......................>...............................>
        1               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  STORE_RESULTS:        >       Store results           >
>.......................>...............................>
        0               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  INT_METHOD:           >       Integration method      >
>.......................>...............................>
        1               > 1 for Euler method            >
                        > 2 for RK                      >
                        > 3 for RKQC                    >
>----------------------->------------------------------->

>----------------------->------------------------------->
  NETWORK:              > Structure of network          >
>.......................>...............................>
        SCell.ntw       > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  OUTPUT_SETUP:         > List of variables for output  >
>.......................>...............................>
        train.ous       > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TREATMENTS:           > External treatments           >
>.......................>...............................>
        train.trt       > the name of the file          >
>----------------------->------------------------------->
  INT_&_FIRE:           >       Integration method      >
>.......................>...............................>
        0.0020000000    > Integrate And Fire step_size  >
>----------------------->------------------------------->

END

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