Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)

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Accession:102279
Serotonergic modulation of the afterhyperpolarization (AHP) contributes to the regulation of the excitability of the leech S cell, a neuron critical for sensitization of the shortening reflex. Pharmacological and physiological data suggest that three currents contribute to the S cell's afterhyperpolarization: a charybdotoxin-sensitive, fast calcium-dependent potassium current (fAHP); a tubocurare-sensitive, calcium-dependent potassium current (mAHP); and, a saxitoxin-sensitive, afterdepolarization current (ADP). This single-compartment model of the S cell is constructed using fAHP, mAHP and ADP currents, and shows that reduction of the conductances to mimic the effects of serotonin is sufficient to enhance excitability (repetitive firing).
Reference:
1 . Burrell BD, Crisp KM (2008) Serotonergic modulation of afterhyperpolarization in a neuron that contributes to learning in the leech. J Neurophysiol 99:605-16 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Leech S cell;
Channel(s): I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s):
Implementer(s): Crisp, Kevin [crisp at stolaf.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I K,leak; I K,Ca; I Sodium;
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leechSCell
readme.txt
ADP.m *
ADP.vdg *
Ca.fBR *
Ca.ion *
Ca.ion.tmp *
Ca.m *
Ca.vdg *
fAHP.m *
fAHP.vdg *
Kdr.m *
Kdr.vdg *
leak.vdg
mAHP.A *
mAHP.vdg *
Na.h *
Na.m *
Na.vdg *
netwf *
netwfile *
ousgrf.def *
SCell.neu
SCell.ntw
simufiles.usd
single.ous
single.ous.mnu
single.smu
single.smu.exec
single.smu.hmn *
single.smu.ing
single.smu.out
single.smu.out.head
single.trt
singlezoom.ous
singlezoom.ous.mnu
singlezoom.smu
singlezoom.smu.exec
singlezoom.smu.hmn *
singlezoom.smu.ing
singlezoom.smu.out
singlezoom.smu.out.head
train.ous
train.ous.mnu
train.smu
train.smu.exec
train.smu.hmn *
train.smu.ing
train.smu.out
train.smu.out.head
train.trt
                            
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		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>    modules name: m		>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
m:		> 	Activation function (rate constant method)	>
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


>----------------------->--------------------------------------->
>	1		>	     am				>
>			>	m= --------		     (1)>
>			>	    am+bm			>
>			>					>
>----------------------->--------------------------------------->
>	2		>	dm/dt=am x (1-m) - bm x m    (2)>
>	0.0	>IV<	>					>
>----------------------->--------------------------------------->
	3		>	dm/dt=L[am x (1-m) - bm x m] (3)>
	0.0	>IV<	>					>
	1000.0	>L<	>					>
>----------------------->--------------------------------------->



		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
am:		> 	Rate parameter (1)				>	
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

>----------------------->----------------------------------------------->
>	1		>	         			(1)	>
>	xxx.xx	>A<	>	am = A        				>
>----------------------->----------------------------------------------->
>	2		>		A (V+B)				>
>	xxx.xx	>A<	>	am = --------------------	(2)	>
>	xxx.xx	>B<	>	          (C-V)/D 			>
>	xxx.xx	>C<	>	     1 + e        			>
>	xxx.xx	>D<	>						>
>			>						>
>----------------------->----------------------------------------------->
	3		>		A (V+B)				>
	1.5	>A<	>	am = --------------------	(3)	>
	-20.0	>B<	>	          (C-V)/D 			>
	20.0	>C<	>	     1 - e        			>
	5.0	>D<	>						>
			>						>
>----------------------->----------------------------------------------->
>	4		>	          (A-V)/B 		(4)	>
>	xxx.xx	>A<	>	am = 1 + e        			>
>	xxx.xx	>B<	>						>
>			>						>
>----------------------->----------------------------------------------->
>	5		>	         (B-V)/C 		(5)	>
>	xxx.xx	>A<	>	am = A e        			>
>	xxx.xx	>B<	>						>
>	xxx.xx	>C<	>						>
>----------------------->----------------------------------------------->
>	6		>		A 				>
>	xxx.xx	>A<	>	am = --------------------	(6)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	7		>		A 				>
>	xxx.xx	>A<	>	am = --------------------	(7)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->
>	8		>		1 				>
>	xxx.xx	>A<	>	am = --------------------	(8)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	9		>		1 				>
>	xxx.xx	>A<	>	am = --------------------	(9)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->

		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
bm:		> 	Rate parameter (2)				>	
		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>

>----------------------->----------------------------------------------->
>	1		>	         			(1)	>
>	xxx.xx	>A<	>	bm = A        				>
>----------------------->----------------------------------------------->
>	2		>		A (V+B)				>
>	xxx.xx	>A<	>	bm = --------------------	(2)	>
>	xxx.xx	>B<	>	          (C-V)/D 			>
>	xxx.xx	>C<	>	     1 + e        			>
>	xxx.xx	>D<	>						>
>			>						>
>----------------------->----------------------------------------------->
>	3		>		A (V+B)				>
>	xxx.xx	>A<	>	bm = --------------------	(3)	>
>	xxx.xx	>B<	>	          (C-V)/D 			>
>	xxx.xx	>C<	>	     1 - e        			>
>	xxx.xx	>D<	>						>
>			>						>
>----------------------->----------------------------------------------->
>	4		>	          (A-V)/B 		(4)	>
>	xxx.xx	>A<	>	bm = 1 + e        			>
>	xxx.xx	>B<	>						>
>			>						>
>----------------------->----------------------------------------------->
	5		>	         (B-V)/C 		(5)	>
	1.5	>A<	>	bm = A e        			>
	-25.0	>B<	>						>
	10.0	>C<	>						>
>----------------------->----------------------------------------------->
>	6		>		A 				>
>	xxx.xx	>A<	>	bm = --------------------	(6)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	7		>		A 				>
>	xxx.xx	>A<	>	bm = --------------------	(7)	>
>	xxx.xx	>B<	>	          (B-V)/C 			>
>	xxx.xx	>C<	>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->
>	8		>		1 				>
>	25.0	>A<	>	bm = --------------------	(8)	>
>	10.0	>B<	>	          (A-V)/B 			>
>			>	     1 + e        			>
>			>						>
>----------------------->----------------------------------------------->
>	9		>		1 				>
>	xxx.xx	>A<	>	bm = --------------------	(9)	>
>	xxx.xx	>B<	>	          (A-V)/B 			>
>			>	     1 - e        			>
>			>						>
>----------------------->----------------------------------------------->
END;

> Ligand
> -------

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