O-LM interneuron model (Lawrence et al. 2006)

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Accession:102288
Exploring the kinetics and distribution of the muscarinic potassium channel, IM, in 2 O-LM interneuron morphologies. Modulation of the ion channel by drugs such as XE991 (antagonist) and retigabine (agonist) are simulated in the models to examine the role of IM in spiking properties.
Reference:
1 . Lawrence JJ, Saraga F, Churchill JF, Statland JM, Travis KE, Skinner FK, McBain CJ (2006) Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. J Neurosci 26:12325-38 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 interneuron oriens alveus GABA cell;
Channel(s): I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;
Gap Junctions:
Receptor(s): Muscarinic;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Oscillations; Detailed Neuronal Models; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 interneuron oriens alveus GABA cell; Muscarinic; I L high threshold; I N; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca;
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RichyandStarfish
readme.html
cad.mod *
ICaL.mod *
ICaT.mod *
Ih.mod
IKa.mod *
IKCa.mod *
Ikdrf.mod *
Ikdrfaxon.mod *
Ikdrs.mod *
Ikdrsaxon.mod *
Ikleakaxon.mod *
Ikleaksd.mod *
IMminret.mod *
IMmintau.mod *
Ipassaxon.mod *
Ipasssd.mod *
Naaxon.mod *
Nadend.mod *
Nasoma.mod *
SIN.mod *
fig9.hoc
initactiveproxRichy.hoc
initactiveproxStarfish.hoc
initactivesdRichy.hoc
initactivesdStarfish.hoc
initsomaRichy.hoc
initsomaStarfish.hoc
mosinit.hoc
Richytrunctest2.hoc
screenshot.jpg
Starfishtrunc.hoc
                            
load_file("nrngui.hoc")

load_file("Starfishtrunc.hoc")
celsius=24

for i=0,8 soma[i] {
	insert passsd
	g_passsd=1.273e-05
	erev_passsd=-59.419
	insert Kleaksd
	gkl_Kleaksd=3.1262e-06
	Ra=300
	cm=0.9
	ek=-95
	insert IM
	gbar_IM = 0.000257
	insert Ikdrf
	gbar_Ikdrf = 0.0006
	insert Ikdrs
	gbar_Ikdrs = 0.00023
	insert Ika
	gbar_Ika = 0.00025
	insert Nasoma
        gna_Nasoma = 0.0107
        ena=90
        insert Ih
        gkhbar_Ih = 0.00005
        eh=-32
}

for i=0,43 dendrite[i] {
	insert passsd
	g_passsd=1.273e-05
	erev_passsd=-59.419
	insert Kleaksd
	gkl_Kleaksd=3.1262e-06
	Ra=300
	cm=0.9
	ek=-95
	insert Ikdrf
        gbar_Ikdrf = 0.0006
        insert Ikdrs
        gbar_Ikdrs = 0.00023
        insert Ika
        gbar_Ika = 0.00025
	insert Nadend
        gna_Nadend = 0.0117
        ena=90
        insert cal
	gcalbar_cal = 0.0025
	insert cad
	insert cat
	gbar_cat=0.00025
	insert kca
	gkbar_kca = 0.00055
}

for i=0,7 axon[i] {insert passaxon
	g_passaxon=4.3282e-05
	erev_passaxon=-59.419
	insert Kleakaxon
	gkl_Kleakaxon=1.0629e-05
	Ra=300
	cm=0.9
	ek=-95
	insert Ikdrf
        gbar_Ikdrf = 0.0006
        insert Ikdrs
        gbar_Ikdrs = 0.00023
	insert Nadend
	gna_Nadend = 0.0117
	ena = 90
} 
                                           
dendrite[1] {insert IM
	gbar_IM = 0.000257}
dendrite[2] {insert IM
	gbar_IM = 0.000257}
dendrite[3] {insert IM
	gbar_IM = 0.000257}
dendrite[4] {insert IM
	gbar_IM = 0.000257}
dendrite[9] {insert IM
	gbar_IM = 0.000257}
dendrite[8] {insert IM
	gbar_IM = 0.000257}
dendrite[7] {insert IM
	gbar_IM = 0.000257}


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