Nerve terminal currents at lizard neuromuscular junction (Lindgren, Moore 1989)

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Accession:10360
Loose patch clamp measurement of presynaptic ionic currents at lizard neuromuscular junction compared with computer simulations.
Reference:
1 . Lindgren CA, Moore JW (1989) Identification of ionic currents at presynaptic nerve endings of the lizard. J Physiol 414:201-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  I Na,t; I K;
/
lindgren89
README
ending.ses
fig13.ses
init.hoc
mosinit.hoc
                            
load_file("nrngui.hoc")
objectvar save_window_, rvp_
objectvar scene_vector_[3]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin CellBuild[0]
{
load_file("celbild.hoc", "CellBuild")
}
{ocbox_ = new CellBuild(1)}
{object_push(ocbox_)}
{
version(5.1)
continuous = 1
}
{object_push(topol)}
{
first = 0
slist.remove_all()
sname = "ax"
objref tobj
}
{
tobj = new CellBuildSection("node",0, 0, tobj, 0) slist.append(tobj)
  tobj.position(-150,0,-135,0) tobj.lx=-143.865 tobj.ly=-14.6412 tobj.i3d=0
tobj = new CellBuildSection("internode",0, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(-135,0,-90,0) tobj.lx=-112.54 tobj.ly=20.5993 tobj.i3d=0
tobj = new CellBuildSection("node",1, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(1)
  tobj.position(-90,0,-75,0) tobj.lx=-85.1307 tobj.ly=-14.6412 tobj.i3d=0
tobj = new CellBuildSection("internode",1, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(2)
  tobj.position(-75,0,-30,0) tobj.lx=-45.9745 tobj.ly=30.3884 tobj.i3d=0
tobj = new CellBuildSection("node",2, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(3)
  tobj.position(-30,0,-15,0) tobj.lx=-22.4808 tobj.ly=-14.6412 tobj.i3d=0
tobj = new CellBuildSection("internode",2, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(4)
  tobj.position(-15,0,27,0) tobj.lx=5.90739 tobj.ly=16.6837 tobj.i3d=0
tobj = new CellBuildSection("heminode",0, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(5)
  tobj.position(27,0,45,0) tobj.lx=38.2112 tobj.ly=-14.6412 tobj.i3d=0
tobj = new CellBuildSection("ax",0, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(6)
  tobj.position(45,0,72,15) tobj.lx=60.726 tobj.ly=1.02125 tobj.i3d=0
tobj = new CellBuildSection("bouton",0, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(7)
  tobj.position(72,15,90,15) tobj.lx=79.3252 tobj.ly=38.2196 tobj.i3d=0
tobj = new CellBuildSection("ax",1, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(8)
  tobj.position(90,15,117.378,28.5431) tobj.lx=112.608 tobj.ly=11.7892 tobj.i3d=0
tobj = new CellBuildSection("bouton",1, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(9)
  tobj.position(117.378,28.5431,135,30) tobj.lx=121.418 tobj.ly=49.9665 tobj.i3d=0
tobj = new CellBuildSection("ax",2, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(10)
  tobj.position(135,30,162.311,43.6698) tobj.lx=154.701 tobj.ly=28.4306 tobj.i3d=0
tobj = new CellBuildSection("bouton",2, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(11)
  tobj.position(162.311,43.6698,180,45) tobj.lx=160.574 tobj.ly=64.65 tobj.i3d=0
tobj = new CellBuildSection("ax",3, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(12)
  tobj.position(180,45,210,60) tobj.lx=199.73 tobj.ly=44.093 tobj.i3d=0
tobj = new CellBuildSection("bouton",3, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(13)
  tobj.position(210,60,225,60) tobj.lx=211.477 tobj.ly=81.2914 tobj.i3d=0
all_init()
}
for i=0, slist.count-1 {slist.object(i).rdses()}
{object_pop()}
{
}
{object_push(subsets)}
{first = 0}
{tobj = new SNList("all_active") snlist.append(tobj)}
for i=0,11 tobj.add(bild.topol.slist.object(fscan()))
0
2
4
6
7
8
9
10
11
12
13
14
{tobj = new SNList("internodes") snlist.append(tobj)}
for i=0,2 tobj.add(bild.topol.slist.object(fscan()))
1
3
5
{tobj = new SNList("nodes") snlist.append(tobj)}
for i=0,3 tobj.add(bild.topol.slist.object(fscan()))
0
2
4
6
{tobj = new SNList("boutons") snlist.append(tobj)}
for i=0,3 tobj.add(bild.topol.slist.object(fscan()))
8
10
12
14
{tobj = new SNList("thin_active") snlist.append(tobj)}
for i=0,4 tobj.add(bild.topol.slist.object(fscan()))
6
7
9
11
13
{consist()}
{object_pop()}
{
}
{object_push(geom)}
{
first = 0
tobj = new GeoSpec(4)
tobj.value = 4
bild.subsets.snlist.object(2).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 4
bild.subsets.snlist.object(2).geo.append(tobj)
tobj = new GeoSpec(4)
tobj.value = 1
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 2
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 4
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(4)
tobj.value = 1
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 5
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 5
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(4)
tobj.value = 1
bild.subsets.snlist.object(5).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 2
bild.subsets.snlist.object(5).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 1
bild.subsets.snlist.object(5).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 200
bild.topol.slist.object(1).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 100
bild.topol.slist.object(3).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 50
bild.topol.slist.object(5).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 4
bild.topol.slist.object(6).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 4
bild.topol.slist.object(6).geo.append(tobj)
tobj = new GeoSpec(0)
tobj.value = 4
bild.topol.slist.object(7).geo.append(tobj)
tobj = new GeoSpec(1)
tobj.value = 2
bild.topol.slist.object(7).geo.append(tobj)
set_default()
}
{object_pop()}
{
}
{object_push(memb)}
{first=0}
{
tobj = new GeoSpec(0)
tobj.value = 300
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new GeoSpec(1)
tobj.value = 2
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("pas")
tobj.set("g_pas", 1e-05, 0)
tobj.set("e_pas", -65, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(2).ml.append(tobj)
}
{
tobj = new GeoSpec(1)
tobj.value = 0.01
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(2).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 1.2, 0)
tobj.set("gkbar_hh", 0.003, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.6, 0)
tobj.set("gkbar_hh", 0.046, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(6).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.4, 0)
tobj.set("gkbar_hh", 0.06, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(7).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.3, 0)
tobj.set("gkbar_hh", 0.171, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(8).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.24, 0)
tobj.set("gkbar_hh", 0.185, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(9).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.2, 0)
tobj.set("gkbar_hh", 0.2, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(10).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.2, 0)
tobj.set("gkbar_hh", 0.218, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(11).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.2, 0)
tobj.set("gkbar_hh", 0.24, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(12).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.15, 0)
tobj.set("gkbar_hh", 0.185, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(13).ml.append(tobj)
}
{
tobj = new MechanismStandard("hh")
tobj.set("gnabar_hh", 0.12, 0)
tobj.set("gkbar_hh", 0.15, 0)
tobj.set("gl_hh", 0.001, 0)
tobj.set("el_hh", -54.3, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(14).ml.append(tobj)
}
{object_pop()}
{
}
{object_push(manage)}
{
first = 0
classname = "Cell"
etop=1 esub=1 egeom=1 emem=1
itop=1 isub=0 igeom=0 imem=0
bild.topol.names_off = 0
bild.topol.circles_off = 0
}
{object_pop()}
{
cexport()
}
{object_pop()}
{
save_window_=ocbox_.gtopol
save_window_.size(-200,200,-150,150)
scene_vector_[2] = save_window_
ocbox_.gtopol = save_window_
save_window_.save_name("ocbox_.gtopol")
}
{
ocbox_.map("CellBuild[0]", 174, 103, 842.88, 246.72)
}
objref ocbox_
//End CellBuild[0]

{WindowMenu[0].ses_gid(1, 0, 0, "presynaptic ending")}
objectvar scene_vector_[1]
{doNotify()}

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