Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)

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Accession:104623
From Zhu and Clancy: "... Here we employ theoretical simulations to examine the effects of a Timothy Syndrome (TS) mutation in the L-type Ca2+ channel on cardiac dynamics over multiple scales, from a gene mutation to protein, cell, tissue, and finally the ECG, to connect a defective Ca2+ channel to arrhythmia susceptibility. ..."
References:
1 . Fox JJ, McHarg JL, Gilmour RF (2002) Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol 282:H516-30 [PubMed]
2 . Zhu ZI, Clancy CE (2007) L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol 293:H3480-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I L high threshold; I Calcium; I Potassium; Na/Ca exchanger; I_Ks; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Temporal Pattern Generation; Heart disease; Long-QT; Timothy Syndrome; Sodium pump;
Implementer(s): Zhu, Zheng I. [zhz2001 at med.cornell.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I Calcium; I Potassium; Na/Ca exchanger; I_Ks; Na/K pump;
 
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